血细胞及其衍生参数在子宫内膜异位症中的意义研究

目的探讨血细胞及其衍生参数如中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、系统性免疫性炎症指数(SII)等对子宫内膜异位症的诊断价值及临床意义。方法选取2018年7月至2019年6月中国医科大学附属盛京医院收治的卵巢异位囊肿手术患者72例(卵巢异位囊肿组)和子宫腺肌病手术患者83例(子宫腺肌病组)作为试验组,卵巢其他良性肿瘤74例作为对照组,检测外周血血细胞计数及血清糖类抗原125(CA125)水平,并计算血细胞衍生参数,分析其在卵巢异位囊肿、子宫腺肌病中的临床意义。结果卵巢异位囊肿组和子宫腺肌病组NLR、SII、CA125水平高于对照组,差异有统计学意义(P<0.05)。子宫腺肌病组患者不同子宫体积的外周血PLR、SII比较,差异有统计学意义(P<0.05)。CA125、PLR与SII的受试者工作特征曲线下面积均大于0.7,对子宫腺肌病辅助诊断价值较高。结论PLR与SII对子宫腺肌病具有较高的诊断价值,可以反映其病情进展。

The significance of complete blood count and its derived parameters in endometriosis

Objective To investigate the diagnostic value of blood cells and their derived markers such as neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),systemic immune-inflammation index(SII)in endometriosis and their correlation with clinical features.Methods From July 2018 to June 2019,72 cases of patients receiving ectopic ovarian cyst surgery(ectopic ovarian cyst group)and 83 cases of patients receiving adenomyosis surgery(adenomyosis group)as the experimental group,74 cases of other benign ovarian tumors as the control group from the Shengjing hospital of China medical university.The peripheral blood sample was extracted to detect the blood cell account and serum carbohydrate antigen 125(CA125)levels.The derived parameters of blood cells were calculated and its clinical significance in ectopic ovarian cyst and adenomyosis was analyzed.Results The levels of NLR,SII and CA125 in ectopic ovarian cyst group and adenomyosis group were higher than those in control group,and the differences were statistically significant(P<0.05).There were statistically significant differences in PLR and SII of peripheral blood of different uterine volumes in adenomyosis group(P<0.05).The area under the receiver operating characteristic curve of CA125,PLR and SII was all greater than 0.7,indicating high value in adjuvant diagnosis of adenomyosis.Conclusion PLR and SII have high diagnostic value in adenomyosis and can reflect the progression of the disease.