PD-L1、B7-H3及B7-H4在宫颈癌免疫治疗中的研究进展

宫颈癌是我国常见的妇科恶性肿瘤,其发生和发展常与免疫逃逸有关,免疫治疗已经成为目前宫颈癌治疗的研究热点.随着免疫检查点程序性死亡配体1(PD-L1)及程序性死亡受体1(PD-1)的抑制剂在多种恶性肿瘤中的成功应用,以PD-L1为代表的共刺激因子与宫颈癌的研究愈发受到关注,其中负性共刺激因子与宫颈癌免疫抑制密切相关.PD...

Research Progress of PD-L1, B7-H3 and B7-H4 in Immunotherapy of Cervical Cance

Cervical cancer is a common gynecological malignancies in China. Its occurrence and development are often related to immune escape. Immunotherapy has become a research hotspot in the treatment of cervical cancer. With the successful application of immune checkpoint programmed death 1 ligand (PD-L1) and programmed death 1 (PD-1) inhibitors in a variety of malignant tumors, the study of costimulatory factors represented by PD-L1 and cervical cancer has attracted more and more attention, among which negative costimulatory factors are closely related to the immunosuppression of cervical cancer. PD-L1, namely B7-H1, is a common negative costimulatory factor along with B7-H3 and B7-H4, which causes immune escape of cancer cells by inhibiting the immune response. Many studies have shown that PD-L1, B7-H3 and B7-H4 are abnormally high expressed in cervical cancer, which inhibits the immune response to cervical cancer cells, and has corresponding clinical significance in the development, invasion, metastasis and prognosis of cervical cancer. This paper reviewed the biological functions of negative costimulatory factors PD-L1, B7-H3 and B7-H4, as well as their expression and application in cervical cancer, in order to provide a new idea for the immunotargeted therapy of cervical cancer.