Hcy、TIMP-1、CCCK-18与高血压性脑出血病情及预后的相关性分析

目的分析血清同型半胱氨酸(Hcy)、基质金属蛋白酶组织抑制剂-1(TIMP-1)、caspase切割的细胞角蛋白18(CCCK-18)水平与高血压性脑出血(HICH)患者病情严重程度及预后评估的相关性。方法将该院2018年1月至2019年8月收治的80例HICH患者作为观察组,同期在该院体检的50例体检健康者作为对照组。患者治疗3个月后采用改良Rankin量表对预后质量进行评估;检测并比较观察组与对照组不同病情严重程度、不同预后质量患者血清中Hcy、TIMP-1、CCCK-18水平;采用Logistic回归模型分析Hcy、TIMP-1、CCCK-18水平与HICH患者病情及预后的相关性。结果观察组患者血清Hcy、TIMP-1、CCCK-18水平明显高于对照组,差异有统计学意义(P<0.05)。随着HICH患者病情严重程度的升高,患者血清中Hcy、TIMP-1、CCCK-18水平随之升高,差异有统计学意义(P<0.05)。预后不佳组患者血清中Hcy、TIMP-1、CCCK-18水平明显高于预后良好组,差异有统计学意义(P<0.05)。患者血清中Hcy、TIMP-1及CCCK-18水平升高是影响HICH患者病情严重程度和预后的独立危险因素(P<0.05)。结论Hcy、TIMP-1、CCCK-18水平与HICH患者病情和预后密切相关,且均为影响患者病情严重程度及预后的独立因素。

Correlation between Hcy,TIMP-1,CCCK-18 and severity and prognosis of hypertensive intracerebral hemorrhage

Objective To analyze the correlation between the levels of serum homocysteine(Hcy),tissue inhibitor of matrix metalloproteinase-1(TIMP-1),caspase cleaved cytokeratin-18(CCCK-18)and the severity and prognosis of patients with hypertensive intracerebral hemorrhage(HICH).Methods Eighty cases of HICH patients in the hospital from January 2018 to August 2019 were selected as observation group and 50 cases of healthy people as control group.After 3 months of treatment,the quality of prognosis was evaluated by modified Rankin scale,and the levels of Hcy,TIMP-1 and CCCK-18 in serum were detected in the observation group and control group,patients with different disease severity,and patients with different prognosis quality.Logistic regression model was used to analyze the correlation between the expression of Hcy,TIMP-1,CCCK-18 and the severity and prognosis of HICH patients.Results The levels of Hcy,TIMP-1 and CCCK-18 in the observation group were significantly HICHer than those in the control group(P<0.05).With the increase of the severity of HICH patients,the levels of Hcy,TIMP-1 and CCCK-18 in serum of patients increased significantly(P<0.05).The levels of Hcy,TIMP-1 and CCCK-18 in poor prognosis group were significantly HICHer than those in good prognosis group(P<0.05).HICH serum Hcy,TIMP-1 and CCCK-18 levels were independent risk factors that affect the severity of disease and the quality of prognosis of HICH patients(P<0.05).Conclusion Hcy,TIMP-1 and CCCK-18 are closely related to the severity and prognosis of HICH patients,and they are all independent factors affecting the severity of disease and the quality of prognosis.