血清Hcy、RBP和Cys C联合检测在妊娠期糖尿病肾病的早期诊断价值

目的探讨联合检测同型半胱氨酸(Hcy)、视黄醇结合蛋白(RBP)及胱抑素C(Cys C)对妊娠期糖尿病肾病(DN)的早期诊断价值。方法选取2012年1月至2019年10月南京医科大学附属妇产医院妊娠期DN患者82例为研究对象,分为早期DN组(44例)和临床DN组(38例),另选择同期同孕周健康孕妇48例为健康对照组。比较3组的Hcy、RBP和Cys C水平;采用受试者工作特征曲线(ROC曲线)分析Hcy、RBP和Cys C对妊娠期DN的早期诊断效能。结果Hcy、RBP、Cys C水平在临床DN组均高于早期DN组,差异有统计学意义(P<0.01)。Hcy、RBP和Cys C 3项指标联合检测的灵敏度高于Hcy和RBP 2项指标联合检测(P<0.05)。Hcy、RBP和Cys C 3项指标联合检测的ROC曲线下面积为0.856。结论Hcy、RBP和Cys C联合检测能够提高妊娠期DN的早期诊断效能。

Early diagnostic value of combined detection of serum Hcy,RBP and Cys C in gestational diabetes nephropathy

Objective To investigate the value of combined detection of homocysteine(Hcy),retinol binding protein(RBP)and cystatin C(Cys C)in early diagnosis of gestational diabetic nephropathy(DN).Methods Eighty-two cases of DN in pregnancy were selected from January 2012 to October 2019 in Obstetrics and Gynecology Hospital of Nanjing Medical University.The subjects were divided into early DN group(44 cases)and clinical DN group(38 cases),and 48 healthy pregnant women of the same pregnancy week were selected as the health control group.The levels of Hcy,RBP and Cys C were compared,and the diagnostic value of Hcy,RBP and Cys C were analyzed by receiver operating characteristic curve(ROC curve).Results The level of Hcy,RBP and Cys C in clinical DN group were higher than those in early DN group(P<0.01).The sensitivity of the combined detection of Hcy,RBP and Cys C were higher than those of the combined detection of Hcy and RBP(P<0.05).The area under the ROC curve of Hcy,RBP and Cys C combined detection was 0.856.Conclusion Combined detection of Hcy,RBP and Cys C can improve the efficiency of early diagnosis of gestational DN.