同型半胱氨酸与不良妊娠结局的关系

同型半胱氨酸(homocysteine,HCY)是蛋氨酸代谢的中间产物,HCY水平升高是心脑血管疾病的独立危险因素.不良妊娠为临床妊娠疾病的一种类型,随着生活环境的改变,发生率逐年升高,但相关发病机制尚不明确.近年研究发现,HCY水平与一系列不良妊娠的发生密切相关,妊娠期女性HCY水平较妊娠前明显下降,对HCY损伤敏感...

Relationship between Homocysteine and Adverse Pregnancy Outcomes

Homocysteine (HCY) is an intermediate product of methionine metabolism. The elevated HCY level is an independent risk factor of cardiovascular and cerebrovascular diseases. Adverse pregnancy is a type of clinical pregnancy diseases. With the change of living environment, the incidence increases year by year. However, the relevant pathogenesis of adverse pregnancy is not clear. In recent years, studies have found that the level of HCY is closely related to the occurrence of a series of adverse pregnancies. The level of HCY in pregnant women is significantly lower than that before pregnancy, and the sensitivity to HCY injury is also enhanced in pregnant women. A slight increase in the level of HCY may lead to a series of vascular damage, and then lead to the occurrence of a series of adverse pregnancies. The major causes of HCY increase are the abnormal levels of enzymes related to HCY production, lack of cofactors, excessive intake of methionine, some diseases and some drugs. The decrease in the HCY level can effectively improve adverse pregnancy, by the reasonable supplement of folic acid and B vitamins and the lifestyle intervention. In this paper, the relationship between HCY and adverse pregnancy outcomes is reviewed in order to provide useful reference for the prevention and treatment of adverse pregnancy.