早发性卵巢功能不全的临床诊疗进展

早发性卵巢功能不全(premature ovarian insufficiency,POI)是指女性40岁前卵巢功能衰退,严重影响育龄女性身心健康.大多数POI病因不明,目前发现的病因有遗传因素、免疫因素和医源性因素等.POI女性生育能力低下,仅依靠激素补充治疗(hormone replacement therapy,...

Advances in Clinical Diagnosis and Treatment of Premature Ovarian Insufficiency

Premature ovarian insufficiency(POI)is characterized by the decline of ovarian function before the age of 40 years,with severe influence on the physical and mental health of women of childbearing age.The etiology of most POIs remains unclear,which currently includes genetic factors,immunological factors and iatrogenic factors.POI patients have the reduced fertility.It is not enough to improve symptoms by hormone replacement therapy(HRT).However,there is no effective treatment so far,especially in terms of fertility preservation.In recent years,assisted reproductive technology has provided certain treatments for POI patients with fertility needs.In addition,the frozen ovarian tissue transplantation and stem cell transplantation may be the new options.This review will describe the progress of clinical diagnosis and treatment of POI.