替罗非班治疗颈动脉漂浮血栓相关脑梗死

颈动脉漂浮血栓为一种细长的血管内漂浮物,多见于颈内动脉,常为动脉粥样硬化斑块破裂所致,可造成血管重度狭窄或者漂浮物脱落导致下游流域内多发脑栓塞,临床表现为神经功能缺损症状,严重者可出现恶性大脑中动脉脑梗死、脑疝等,并危及生命。其发病率及识别率低、病因多样,治疗方法包括颈内动脉支架置入术、颈内动脉内膜剥脱术以及抗凝、抗血小板聚集等治疗,但目前尚无指南可循。现报道应用替罗非班成功治疗颈动脉漂浮血栓相关脑梗死患者1例,以提高对颈动脉漂浮血栓相关脑梗死的认识,并为其治疗提供新的思路。

Tirofiban in the treatment of cerebral infarction associated with carotid artery floating thrombus: a case report and literature review

Carotid artery floating thrombus is a type of slender intravascular floating objects,which is frequently seen in the internal carotid artery.It is often caused by ruptured atherosclerotic plaques,which can cause severe vascular stenosis or multiple cerebral em?bolism in the downstream region due to the shedding of floating objects,with clinical manifestations of neurological deficits,and even cause malignant cerebral infarction of the middle cerebral artery and cerebral herniation,thus threatening the life.Its morbidity and recognition rate are low,and the causes are diverse.The treatment methods include internal carotid artery stenting,internal carotid endarterectomy,anticoagulation,and antiplatelet aggregation.However,there are no guidelines to follow.In this article,a case of ce?rebral infarction related to carotid artery floating thrombus was successfully treated with tirofiban to improve the understanding of cere?bral infarction related to carotid artery floating thrombus and to provide new ideas for its treatment.