| 地中海贫血的影像学研究进展 |
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| 引用本文： | 刘心怡,莫潼,曾洪武. 地中海贫血的影像学研究进展[J]. 国际医学放射学杂志, 2021, 44(2): 147-151. DOI: 10.19300/j.2021.Z18320 |
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| 作者姓名： | 刘心怡 莫潼 曾洪武 |
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| 作者单位： | 深圳市儿童医院放射科,深圳 518000;汕头大学医学院;深圳市儿童医院放射科,深圳 518000 |
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| 基金项目： | 深圳市医疗卫生三名工程项目(SZSM202011005)。 |
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| 摘 要： | 地中海贫血（TM）是一种常见的珠蛋白基因缺失或突变引起的遗传性溶血性贫血。X线、CT与常规MRI有助于诊断及评估TM骨骼病变及髓外造血。基于MRI的T2*定量分析技术、扩散加权成像及磁敏感加权成像可对比分析TM多脏器铁沉积水平。磁共振波谱成像及功能MRI可进一步研究TM神经认知方面的代谢改变及脑区功能连接。就上述各种影像方法在TM骨骼病变、髓外造血、铁沉积及继发脑认知功能改变中的研究进展予以综述。
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| 关 键 词： | 地中海贫血 磁共振成像 体层摄影术 X线计算机 |
| 收稿时间： | 2020-05-22 |
Progress in thalassemia imaging |
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| LIU Xinyi,MO Tong,ZENG Hongwu. Progress in thalassemia imaging[J]. International Journal of Medical Radiology, 2021, 44(2): 147-151. DOI: 10.19300/j.2021.Z18320 |
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| Authors: | LIU Xinyi MO Tong ZENG Hongwu |
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| Affiliation: | 1 Department of Radiology, Shenzhen Children’s Hospital, Shenzhen 518000, China
2 Shantou University Medical College |
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| Abstract: | Thalassemia is a common genetic hemolytic anemia due to the mutations or deletions of relevant globingene.X rays,CT,and conventional MRI are useful for diagnosing and evaluating bone lesions and extramedullary hematopoiesis in thalassemia.MRI T2*relaxometry methods,diffusion weighted imaging,and susceptibility weighted imaging contribute to iron overload assessment of multiple organs in thalassemia patients.Neurocognitive metabolism and functional connectivities of those patients can be displayed even further by magnetic resonance spectroscopy and functional MRI.This article summarizes the progress of the above imaging methods in skeletal lesions,extramedullary hematopoiesis,iron deposition,and neurocognitive changes in thalassemia. |
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| Keywords: | Thalassemia Magnetic resonance imaging Tomography,X-ray computed |
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