血清免疫球蛋白E在心力衰竭患者中的水平及临床意义

目的探讨免疫球蛋白(Ig)E在心力衰竭患者中的水平及临床意义。方法选取该院2019年6—12月101例心力衰竭患者为心力衰竭组,其中63例冠状动脉粥样硬化性心脏病(简称冠心病)性心力衰竭(CHD)患者为CHD组,38例其他原因所致心力衰竭(NCHD)患者为NCHD组,同时随机选取224例冠心病患者为冠心病组,86例体检健康者为健康对照组。采集连续入组的血清标本,采用免疫透射比浊法检测血清IgE水平。采用Spearman相关分析血清IgE水平与B型钠尿肽(BNP)、舒张压、低密度脂蛋白胆固醇(LDL-C)等指标的相关性。结果心力衰竭组和冠心病组血清IgE水平高于健康对照组,差异有统计学意义(P<0.05);CHD组血清IgE水平高于冠心病组和NCHD组,差异有统计学意义(P<0.05);Spearman相关分析结果显示,CHD患者血清IgE水平与舒张压、BNP呈正相关(r=0.330、0.346,均P<0.05),与LDL-C呈负相关(r=-0.238,P<0.05)。IgE联合BNP诊断效能较高。结论血清IgE水平在CHD患者中升高,且与心功能状态相关。IgE与BNP联合诊断可以提高CHD的诊断效能,对于心力衰竭病因具有辅助诊断价值。

The level and clinical significance of serum immunoglobulin E in patients with heart failure

Objective To investigate the level and clinical significance of immunoglobulin(Ig)E in patients with heart failure.Methods From June to December 2019,101 patients with heart failure in this hospital were selected as the heart failure group,of which 63 patients with coronary atherosclerotic heart disease(abbreviated as coronary heart disease)and heart failure(CHD)were selected as the CHD group,38 patients with heart failure due to other causes(NCHD)were included in the NCHD group.At the same time,224 patients with coronary heart disease were randomly selected as the coronary heart disease group,and 86 healthy patients were selected as the healthy control group.Serum samples from consecutive groups were collected,and serum IgE level was detected by immunoturbidimetric method.Spearman was used to analyze the correlation between serum IgE and B-type natriuretic peptide(BNP),diastolic blood pressure,low-density lipoprotein cholesterol(LDL-C)and other indicators.Results The serum IgE level of the heart failure group and the coronary heart disease group were higher than that of the healthy control group,and the differences were statistically significant(P<0.05);the serum IgE level of the CHD group was higher than that of the coronary heart disease group and the NCHD group,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that serum IgE level in CHD patients were positively correlated with diastolic blood pressure and BNP(r=0.330,0.346,both P<0.05),and negatively correlated with LDL-C(r=-0.238,P<0.05).IgE combined with BNP had higher diagnostic efficiency.Conclusion Serum IgE level is elevated in CHD patients and is related to the state of cardiac function.The combined diagnosis of IgE and BNP can improve the diagnostic efficiency of CHD,and has an auxiliary diagnostic value for the etiology of heart failure.