Apelin在多囊卵巢综合征中的研究进展

多囊卵巢综合征（PCOS）是最常见的女性内分泌疾病,以慢性无排卵和高雄激素血症为特征,其病因复杂,临床表现高度异质,不仅影响女性生殖和内分泌系统,还常伴随多种代谢异常,包括胰岛素抵抗、高胰岛素血症、肥胖等。Apelin是脂肪因子家族新成员,是由脂肪细胞分泌的一类活性肽激素,主要参与体液平衡、食物摄入、胰岛素分泌、能量代谢等生理过程。具有改善胰岛素抵抗,增强胰岛素敏感性的作用。近年研究发现,PCOS患者血清Apelin浓度升高,尤其在伴有肥胖和胰岛素抵抗的患者中升高更为明显,这可能与其参与PCOS相关的代谢紊乱有关。因此,Apelin作为一种新的生物学指标,可能参与到PCOS发病及其代谢紊乱过程,因而有望成为治疗PCOS的新靶点。

Research Progress of Apelin in Polycystic Ovary Syndrome

Polycystic ovary syndrome(PCOS)is the most common female endocrine disease,which is characterized by chronic anovulation and hyperandrogenemia,with complex etiology and highly heterogeneous clinical manifestations.PCOS not only affects female reproduction and endocrine system,but also is often accompanied with a variety of metabolic abnormalities,including insulin resistance(IR),hyperinsulinemia,obesity and so on.Apelin,a new member of adipokines family,is a kind of active peptide hormone secreted by adiposity.Apelin is mainly involved in many physiological processes,such as fluid balance,food intake,insulin secretion and energy metabolism.It can reverse IR and enhance insulin sensitivity.In recent years,it has been observed that the elevated level of serum Apelin in PCOS patients,especially in those patients with obesity and IR,may be related to the abnormal proliferation of granulosa cells and the related metabolic disorders.Therefore,Apelin as a novel biological indicator may be involved in the pathogenesis of PCOS and its metabolic disorders,so it is expected to become a potential target for the treatment of PCOS.