血清miR-21、sICAM-1和CA153联合检测对乳腺癌的早期诊断价值

目的探讨血清miR-21、可溶性细胞间黏附分子1(sICAM-1)和糖类抗原153(CA153)联合检测对乳腺癌的早期诊断价值。方法选取2016年1月至2019年12月在南京医科大学附属妇产医院诊断为乳腺癌的患者31例为恶性肿瘤组,选择同期活组织检测为乳房良性病变患者31例为良性肿瘤组,选择同期该院体检健康者31例为健康对照组。比较3组血清miR-21、sICAM-1、CA153水平,并对miR-21、sICAM-1和CA153单项及联合检测早期诊断乳腺癌的灵敏度、特异度、阴性预测值、阳性预测值、诊断效率进行比较。结果血清miR-21、sICAM-1、CA153水平在恶性肿瘤组明显高于良性肿瘤组,差异有统计学意义(P<0.05)。血清miR-21、sICAM-1、血清CA153联合检测早期诊断乳腺癌的灵敏度、阳性预测值和诊断效率与miR-21单项检测比较,差异有统计学意义(P<0.05);血清miR-21、sICAM-1、CA153联合检测早期诊断乳腺癌的灵敏度、阴性预测值、阳性预测值和诊断效率与sICAM-1单项检测比较,差异有统计学意义(P<0.05);血清miR-21、sICAM-1、CA153联合检测早期诊断乳腺癌的灵敏度、特异度、阴性预测值、阳性预测值和诊断效率与CA153单项检测比较,差异有统计学意义(P<0.05)。血清miR-21、sICAM-1、CA153联合检测用于乳腺癌早期诊断的受试者工作特征曲线下面积为0.891。结论血清miR-21、sICAM-1、CA153联合检测能够显著提高临床对乳腺癌的早期诊断效率。

Value of combined detection of serum miR-21,sICAM-1 and CA153 in early screening and diagnosis of breast cancer

Objective To investigate the clinical value of combined detection of serum miR-21,soluble intercellular adhesion molecule-1(sICAM-1)and carbohydrate antigen 153(CA153)in early diagnosis of breast cancer.Methods From January 2016 to December 2019,31 patients diagnosed with breast cancer in Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University were selected as the malignant tumor group,31 patients diagnosed with benign breast lesions by biopsy during the same period were selected as the benign tumor group,and 31 healthy people in the hospital during the same period were selected as the healthy control group.The serum levels of miR-21,sICAM-1 and CA153 were compared among the three groups,and the sensitivity,specificity,negative predictive value,positive predictive value and diagnostic efficiency of single and combined detection of miR-21,sICAM-1 and CA153 for early diagnosis of breast cancer were compared.Results The levels of miR-21,sICAM-1 and CA153 in malignant tumor group were significantly higher than those in benign tumor group(P<0.05).The sensitivity,positive predictive value and diagnostic efficiency of combined detection of miR-21,sICAM-1 and CA153 for early diagnosis of breast cancer were significantly different from those of single detection of miR-21(P<0.05).The sensitivity,negative predictive value,positive predictive value and diagnostic efficiency of combined detection of miR-21,sICAM-1 and CA153 for early diagnosis of breast cancer were significantly different from those of single detection of sICAM-1(P<0.05).The sensitivity,specificity,negative predictive value,positive predictive value and diagnostic efficiency of combined detection of miR-21,sICAM-1 and CA153 for early diagnosis of breast cancer were significantly different from those of single detection of CA153(P<0.05).The area under the receiver operating characteristic curve of miR-21,sICAM-1 and CA153 combined detection for early diognosis of breast cancer was 0.891.Conclusion Combined detection of serum miR-21,sICAM-1 and CA153 can significantly improve the clinical efficiency of early diagnosis of breast cancer.