| DNA甲基化在乳腺癌中的研究进展 |
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| 引用本文： | 邓长娟. DNA甲基化在乳腺癌中的研究进展[J]. 国际检验医学杂志, 2021, 42(9): 1134-1138 |
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| 作者姓名： | 邓长娟 |
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| 作者单位： | 湖南中医药大学,湖南长沙 410001 |
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| 基金项目： | 湖南省自然科学基金项目(2020JJ4481)。 |
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| 摘 要： | 随着DNA甲基化在乳腺癌中的分子机制逐渐被发现,得到临床的广泛认识和重视.DNA启动子高度甲基化会引起基因沉默,进而表达失调,并以此调控乳腺癌的发生 、发展,并且DNA甲基化检测能作为乳腺癌临床诊断及预后的生物标志物,为乳腺癌的治疗提供新的靶标,因此,DNA甲基化在乳腺癌中有重要价值和广阔的应用前景.本文综述DNA甲基...
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| 关 键 词： | DNA甲基化 乳腺癌 肿瘤标志物 靶点治疗 检测方法 |
Research progress of DNA methylation in breast cancer |
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| Affiliation: | (Hunan University of Traditional Chinese Medicine,Changsha,Hunan 410001,China;Department of Medical Laboratory and Pathology Center,the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha,Hunan 410000,China) |
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| Abstract: | In recent years,the molecular mechanism of DNA methylation in breast cancer has been gradually discovered,and it has also been widely recognized and valued in clinical practice.DNA promoter hypermethylation can cause gene silencing,and then expression imbalance,and regulate the occurrence and development of breast cancer.DNA methylation detection can be used as a biomarker for clinical diagnosis and prognosis of breast cancer,and provide a new target for the treatment of breast cancer.DNA methylation has important value and broad application prospects in breast cancer.This article reviews the molecular mechanism of DNA methylation in the occurrence and development of breast cancer and its research progress in early screening,prognosis and target therapy,and puts forward suggestions and prospects for future research. |
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| Keywords: | DNA methylation breast cancer tumor marker target therapy detection method |
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