阻塞性睡眠呼吸暂停低通气综合征患者VEGF、CTRP5和NLR的检测及临床意义

目的 探讨阻塞性睡眠呼吸暂停低通气综合征(OSA HS)患者外周血血管内皮生长因子(VEGF)、补体C1q/肿瘤坏死因子相关蛋白5(CTRP5)水平和中性粒细胞/淋巴细胞比值(NLR)的变化及其与病情严重程度的关系.方法 选取OSA HS患者84例,依据低通气指数将其分为轻度OSAHS组(33例)和中重度OS-AHS组...

Detection and clinical significance of VEGF,CTRP5 and NLR in patients with obstructive sleep apnea hypopnea syndrome

Objective To investigate the changes of the levels of the peripheral blood vascular endothelial growth factor(VEGF),complement C1q/tumor necrosis factor related protein 5(CTRP5)and neutrophil-to-lymphocyte ratio(NLR)in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)and their relationship with the severity of the disease.Methods A total of 84 patients with OSAHS were selected and divided into mild OSAHS group(33 cases)and moderate-severe OSAHS group(51 cases)according to the hypoventilation index.Another 35 healthy subjects were selected as the control group.The serum VEGF,CTRP5 levels and NLR in the three groups and the changes of these indicators in the two groups of OSAHS patients before and after nasal continuous positive airway pressure were compared;Pearson correlation was used to analyze the correlation between NLR and serum VEGF and CTRP5.Results The levels of serum VEGF,CTRP5 and NLR in the mild OSAHS group and the moderate-severe OSAHS group were higher than those of the control group,and the moderate-severe OSAHS group was higher than the mild OSAHS group(all P<0.05).The levels of serum VEGF,CTRP5 and NLR in the two groups of OSAHS patients after treatment were lower than those before treatment(all P<0.05).There was a positive correlation between NLR and serum VEGF and CTRP5 in the two groups of OSAHS patients(r=0.373,0.409,P<0.05).Conclusion The levels of serum VEGF,CTRP5 and NLR of OSAHS patients are elevated,it is possible to evaluate the severity of the disease and predict the therapeutic effect by detecting the serum levels of VEGF,CTRP5 and NLR in patients with OSAHS.