阻塞性睡眠呼吸暂停低通气综合征患者VEGF、CTRP5和NLR的检测及临床意义

目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者外周血血管内皮生长因子(VEGF)、补体C1q/肿瘤坏死因子相关蛋白5(CTRP5)水平和中性粒细胞/淋巴细胞比值(NLR)的变化及其与病情严重程度的关系。方法选取OSAHS患者84例,依据低通气指数将其分为轻度OSAHS组(33例)和中重度OSAHS组(51例),另选取35例体检健康者作为对照组。比较3组血清VEGF、CTRP5水平及NLR,以及2组OSAHS患者经鼻持续气道正压通气治疗前后上述指标变化情况;采用Pearson相关分析NLR与血清VEGF、CTRP5的相关性。结果轻度OSAHS组、中重度OSAHS组血清VEGF、CTRP5水平及NLR高于对照组,且中重度OSAHS组高于轻度OSAHS组(均P<0.05)。2组OSAHS患者治疗后血清VEGF、CTRP5水平及NLR均低于治疗前(均P<0.05)。2组OSAHS患者NLR与血清VEGF、CTRP5呈正相关(r=0.373、0.409,P<0.05)。结论OSAHS患者血清VEGF、CTRP5水平及NLR均升高,临床可能通过检测OSAHS患者血清VEGF、CTRP5水平及NLR评估患者病情的严重程度,并预测治疗效果。

Detection and clinical significance of VEGF,CTRP5 and NLR in patients with obstructive sleep apnea hypopnea syndrome

Objective To investigate the changes of the levels of the peripheral blood vascular endothelial growth factor(VEGF),complement C1q/tumor necrosis factor related protein 5(CTRP5)and neutrophil-to-lymphocyte ratio(NLR)in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)and their relationship with the severity of the disease.Methods A total of 84 patients with OSAHS were selected and divided into mild OSAHS group(33 cases)and moderate-severe OSAHS group(51 cases)according to the hypoventilation index.Another 35 healthy subjects were selected as the control group.The serum VEGF,CTRP5 levels and NLR in the three groups and the changes of these indicators in the two groups of OSAHS patients before and after nasal continuous positive airway pressure were compared;Pearson correlation was used to analyze the correlation between NLR and serum VEGF and CTRP5.Results The levels of serum VEGF,CTRP5 and NLR in the mild OSAHS group and the moderate-severe OSAHS group were higher than those of the control group,and the moderate-severe OSAHS group was higher than the mild OSAHS group(all P<0.05).The levels of serum VEGF,CTRP5 and NLR in the two groups of OSAHS patients after treatment were lower than those before treatment(all P<0.05).There was a positive correlation between NLR and serum VEGF and CTRP5 in the two groups of OSAHS patients(r=0.373,0.409,P<0.05).Conclusion The levels of serum VEGF,CTRP5 and NLR of OSAHS patients are elevated,it is possible to evaluate the severity of the disease and predict the therapeutic effect by detecting the serum levels of VEGF,CTRP5 and NLR in patients with OSAHS.