羟氯喹在改善胎盘源性妊娠并发症中的应用及研究进展

羟氯喹(hydroxychloroquine,HCQ)是一种传统抗疟药,主要具有抑制细胞自噬的作用,因其母胎安全性,可用于计划妊娠的自身免疫性疾病患者,并被推荐孕前、孕期持续应用.近年来HCQ在妊娠中的应用愈发受到重视,由于其免疫调节和内皮保护作用,在自身免疫性疾病(如系统性红斑狼疮、抗磷脂综合征)合并妊娠的患者中有明...

Advances in Research on Hydroxychloroquine in the Improvement of Placenta-Mediated Pregnancy Complication

Hydroxychloroquine (HCQ) is a widely used antimalarial drug that inhibits cellular autophagy. HCQ can be used in women with rheumatic diseases who planning pregnancy and is recommended for continued use during pregnancy. In recent years, the use of HCQ in pregnancy has received increasing attention due to its immunomodulatory and endothelial protection effects in autoimmune diseases. There is a clear benefit in pregnant patients with autoimmune diseases, such as systemic lupus erythematosus and antiphospholipid syndrome, but it remains unclear whether there is a general benefit for patients without autoimmune diseases. HCQ has anti-inflammatory, immune regulation, anticoagulant, antithrombotic, antioxidant and endothelial protection effects. The modulation of immunity in pregnancy can be multifaceted, multi-level. This paper discusses the mechanisms and advances in the use of HCQ in pregnancy and the improvement of placenta-derived pregnancy complications.