冠心病合并心力衰竭患者血清Cat S、Periostin、NT-proBNP水平与心功能指标、炎症因子的关系研究

目的 探讨冠心病合并心力衰竭患者血清组织蛋白酶S(Cat S)、Periostin及氨基末端脑钠肽前体(NT-proBNP)的水平及其与心功能指标、炎症因子的相关性.方法 选取该院2017年2月至2019年5月收治的冠心病患者100例进行研究.将冠心病患者按照是否合并心力衰竭分成冠心病组(54例)与心力衰竭组(46例)...

Study on the relationship between serum Cat S,Periostin,NT-proBNP levels in patients with coronary heart disease complicated with heart failure and its correlation with cardiac function indexes,inflammatory factors

Objective To explore the expression of serum cathepsin S(Cat S),Periostin and N-terminal Pro brain natriuretic peptide(NT-proBNP)in patients with coronary heart disease complicated with heart failure and its correlation with cardiac function index and inflammatory factor level.Methods Totally 100 patients with coronary heart disease admitted to the hospital from February 2017 to May 2019 were selected for the study.They were divided into coronary heart disease group(54 cases)and heart failure group(46 cases)according to whether they were complicated with heart failure.Another 50 physical examination of healthy volunteers were selected as the control group.The levels of serum Cat S,Periodin,NT-proBNP,cardiac function indexes and inflammatory factors were compared among the three groups,and the correlation between serum Cat S,Periodin,NT-proBNP and cardiac function indexes and inflammatory factors in patients with coronary heart disease and heart failure was analyzed.Results The levels of serum Cat S,Periostin,NT-proBNP,left ventricular mass index(LVMI),left ventricular end diastolic volume(LVEDV),left ventricular end diastolic diameter(LVEDD),interleukin(IL)-1,IL-6 and tumor necrosis factorα(TNF-α)in coronary heart disease group and heart failure group were higher than those in control group,and the above indexes in heart failure group were higher than those in coronary heart disease group(P<0.05).The levels of left ventricular ejection fraction(LVEF)and IL-10 in coronary heart disease group and heart failure group were lower than those in control group,and the levels of LVEF and IL-10 in heart failure group were lower than those in coronary heart disease group(P<0.05).Pearson correlation analysis showed that Cat S,Periostin and NT-proBNP were negatively correlated with LVEF and IL-10(P<0.05),which were positively correlated with LVMI,LVEDV,LVEDD and serum IL-1,IL-6 and TNF-αlevels(P<0.05).Conclusion The serum levels of Cat S,Periostin and NT-proBNP in patients with coronary heart disease complicated with heart failure were significantly increased,and they were closely related to cardiac function indexes and inflammatory factors.They may participate in the pathological process of heart failure in patients with coronary heart disease by promoting the expression of IL-1,IL-6 and TNF-αand inhibiting the expression of IL-10.