肺炎支原体肺炎患儿血浆miR-223、miR-21水平变化及其与T淋巴细胞亚群、炎症因子的关系研究

目的 研究肺炎支原体肺炎(MPP)患儿血浆miR-223、miR-21水平变化及其与T淋巴细胞亚群、炎症因子的关系.方法 选取2017年2月至2019年2月该院收治的MPP患儿120例(观察组)及在该院体检的健康儿童120例(对照组)为研究对象,检测并比较2组血浆miR-223、miR-21、外周血T淋巴细胞亚群、血清...

Changes of plasma miR-223 and miR-21 levels in children with Mycoplasma pneumoniae pneumonia and their relationship with T lymphocyte subsets and inflammatory factors

Objective To study the changes of plasma miR-223 and miR-21 levels in children with Mycoplasma pneumoniae pneumonia(MPP)and their relationship with T lymphocyte subsets and inflammatory factors.Methods Totally 120 MPP children(observation group)and 120 healthy children(control group)in the hospital from February 2017 to February 2019 were selected as the research objects.The levels of plasma miR-223,miR-21,peripheral blood T lymphocyte subsets,interleukin(IL)-6,IL-8 and tumor necrosis factor-α(TNF-α)were detected and compared between the two groups.Pearson correlation was used for correlation analysis.Results The levels of plasma miR-223,miR-21 and serum IL-6,IL-8,TNF-αin the observation group were higher than those in the control group,while the peripheral blood CD3^+,CD4^+,CD8^+T lymphocyte and CD4^+/CD8^+were lower than those in the control group(P<0.05).Pearson correlation analysis showed that,plasma miR-223 and miR-21 in observation group were negatively correlated with peripheral blood CD3^+,CD4^+,CD8^+T lymphocyte and CD4^+/CD8^+(P<0.05),positively correlated with serum IL-6,IL-8 and TNF-α(P<0.05).Conclusion The plasma levels of miR-223 and miR-21 were higher in MPP children,which were closely related to T lymphocyte subsets and inflammatory factors.