| 循环肿瘤细胞的“旧语新说” |
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| 引用本文： | 王砚春,杨晓蓉,郭林,卢仁泉.循环肿瘤细胞的“旧语新说”[J].国际检验医学杂志,2021(7). |
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| 作者姓名： | 王砚春 杨晓蓉 郭林 卢仁泉 |
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| 作者单位： | 复旦大学附属肿瘤医院检验科;复旦大学上海医学院肿瘤学系 |
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| 摘 要： | 循环肿瘤细胞(CTC)是指游离在循环体液中的肿瘤细胞;CTC检测避免了侵入性组织活检的局限性,取材便捷、无创,在动态反映肿瘤状态、疗效监测与预后评估中有重要作用。目前,应用于临床的CTC计数是评估乳腺癌、前列腺癌和结直肠癌预后的有效指标;CTC携带的肿瘤特异性抗原与核酸分析的转化研究,将有助于提高CTC的捕获效率与诊断性能。虽然CTC检测技术的临床应用仍然面临着诸多挑战,但是其在肿瘤诊疗上的潜力不容小觑,具有广阔的应用前景。
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| 关 键 词： | 循环肿瘤细胞 肿瘤诊疗 临床应用 |
"Old words and new sayings"of circulating tumor cells |
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| WANG Yanchun,YANG Xiaorong,GUO Lin,LU Renquan."Old words and new sayings"of circulating tumor cells[J].International Journal of Laboratory Medicine,2021(7). |
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| Authors: | WANG Yanchun YANG Xiaorong GUO Lin LU Renquan |
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| Institution: | (Department of Clinical Laboratory,Fudan University Shanghai Cancer Center,Shanghai 200032,China;Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China) |
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| Abstract: | Circulating tumor cells(CTC)refer to tumor exfoliated cells that are free in circulating body fluids.CTC detection avoids the limitations of invasive tissue biopsy,which is convenient and non-invasive,and plays an important role in dynamically reflecting tumor status,monitoring curative efficacy and evaluating prognosis.At present,the CTC count used in clinic practice is an effective prognostic indicator of breast cancer,prostate cancer and colorectal cancer.Additionally,the translational study of tumor specific antigen and nucleic acid analysis carried by CTC will help to improve the capture efficiency and diagnostic performance of CTC.Although the clinical application of CTC detection technology still faces many challenges,its potential in tumor diagnosis and treatment can not be underestimated and has broad application prospects in the future. |
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| Keywords: | circulating tumor cells tumor diagnosis and treatment clinical application |
| 本文献已被 CNKI 维普 等数据库收录！ |
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