音猬因子信号通路在宫腔粘连纤维化中的研究进展

宫腔粘连(intrauterine adhesion,IUA)主要机制包括子宫内膜基底层损伤、子宫内膜修复障碍和纤维化愈合,进而导致女性闭经、月经过少、复发性流产或生育能力低下.子宫内膜纤维化与IUA的发展有关,但目前对IUA的分子机制尚不清楚.音猬因子(Sonic hedgehog,SHH)信号通路在胚胎发育、组织再...

Research Progress of Sonic Hedgehog Signaling Pathway in Intrauterine Adhesion Fibrosis

The main mechanisms of intrauterine adhesion (IUA) include endometrial basal layer injury, endometrial repair disorders and fibrotic healing, which leads to amenorrhea, oligomenorrhea, recurrent pregnancy loss or low fertility. Endometrial fibrosis is related to the development of IUA, but the cellular and molecular mechanisms of IUA are still unclear. The sonic hedgehog (SHH) signaling pathway plays a key role in embryonic development, tissue regeneration and organogenesis. In recent years, more and more studies have shown that SHH signaling is involved in the pathogenesis of fibrosis in various tissues. The activated SHH signaling pathway participates in the induction of epithelial-mesenchymal transition (EMT) and tissue fibrosis, and promotes the transformation and fibrosis of fibroblasts into myofibroblasts. SHH signals are activated in IUA diseases, indicating that there is a potential link between the abnormal regulation of this signal and endometrial fibrosis. This review summarizes the research progress of SHH signaling pathway and IUA fibrosis.