血清HGF、IL-6水平对血液透析患者蛋白质-能量消耗的诊断价值

目的 探讨血清肝细胞生长因子(HGF)、白细胞介素6(IL-6)水平对血液透析患者蛋白质-能量消耗的诊断价值.方法 选取2014年1月至2017年12月在该院接受血液透析治疗的122例终末期肾病患者为研究对象,分为蛋白质-能量消耗组和非蛋白质-能量消耗组.观察患者临床指标及血清HGF、IL-6水平差异,分析血液透析患者...

Diagnostic value of serum HGF and IL-6 levels for protein energy consumption in hemodialysis patients

Objective To investigate the diagnostic value of serum levels of hepatocyte growth factor(HGF)and interleukin 6(IL-6)in patients with hemodialysis.Methods Totally 122 patients with end-stage renal disease in the hospital from January 2014 to December 2017 who received hemodialysis were selected and divided into protein energy consumption group and non protein energy consumption group.The clinical indicators and serum HGF,IL-6 levels were observed between the two groups,and the risk factors of protein energy consumption in hemodialysis patients were analyzed,and the diagnostic value of serum HGF and IL-6 for protein energy consumption secondary to hemodialysis was discussed.Results There were 37 cases in protein energy consumption group and 85 cases in non protein energy consumption group.The age,dialysis month age,blood urea nitrogen,HGF and IL-6 levels in protein energy consumption group were significantly higher than those in non protein energy consumption group,while body mass index,serum transferrin,albumin,prealbumin and hemoglobin levels in protein energy consumption group were lower than those in non protein energy consumption group(P<0.05).Serum HGF and IL-6 levels were negatively correlated with the levels of serum transferrin,albumin,prealbumin,hemoglobin,total cholesterol and triglycerides in hemodialysis patients(P<0.05).Multivariate regression analysis showed that older age,longer dialysis month age,high serum HGF and IL-6 levels were independent risk factors of protein energy consumption in hemodialysis patients(P<0.05).The area under the receiver operating characteristic curve of HGF and IL-6 combined detection in diagnosing protein energy consumption of hemodialysis patients was 0.910,the sensitivity and specificity were 91.9%and 80.0%,respectively.Conclusion Serum HGF and IL-6 levels can be used as a reference index for screening protein energy consumption in hemodialysis patients.