肺原发性软骨肉瘤2例及文献复习

目的：探讨肺原发性软骨肉瘤的临床病理特征及组织发生。方法：通过ＨＥ、组化及免疫组化观察２例肺原发性软骨肉瘤，并复习文献。结果：肿瘤由粘液亲基质和疏网状结构的梭形细胞及软骨母细胞组成，例２还存在幼稚小圆细胞，三种细胞梯度移行。组化染色显示ＡＢ（ｐＨ２．５）、ＴＢ（ｐＨ４．０）阳性。免疫组化染色显示梭形细胞及软骨母细胞Ｓ－１００蛋白、ｖｉｍｅｎｔｉｎ和ＮＳＥ阳性，例２Ｓｙｎ阳性。小圆细胞ＣＤ９９、Ｓ－

Primary chondrosarcoma of the lung:Report of 2 cases and review of literatuse

Purpose To study the clinicopathological features and histogenesis of primary chondrosarcoma of the lung. Methods Two cases of primary chondrosarcomas of the lung were by HE,histochemical and immunohistochemical stains and literature review. Results The tumor usually appeared as myxoid, slender interanastomosing structure composed of spindled cells and chondroblasts. One case had primitive small round cells with morphogic transition to spindle and chondrobiastoid. Histochemical staining showed AB(pH 2 5) and TB(pH 4 0). Immunohistochemical assay showed reactivity for S 100 protein, vimentin and NSE in spindle cells and chondroblast cells. Syn positive, small round cells were positive for CD99, S 100 protein and NSE. Conclusion Primary chondrosarcoma of the lung is a rare neoplasm, that may originate from small bronchial cartilage and pulmonary primitive mesenchymal tissue. The tumor can be divided into hilum and lung types which have a different prognosis.