地塞米松对家兔急性实验性血清病的调节作用

本实验观察了不同时间及剂量的地塞米松(DX)对家兔急性实验性血清病(AESS)的调节作用。结果发现DX并不抑制AESS家兔特异性抗体的产生。相反,早期给药组动物抗体水平还有增高趋势,循环免疫复合物(CIC)水平显著高于晚期给药及阳性对照组。晚期给药各组特异性抗体,CIC水平及肾组织超氧化物歧化酶活力与阳性对照组无显著差别,但肾组织非特异性酯酶染色及病理学改变明显减轻,提示DX可能是通过减少单核细胞在肾小球内的聚集而减轻AESS的病理改变。氧自由基在AESS发病中的作用尚待进一步探讨。

The Regulatory Effects of Dexamethasone on the Acute Experimental Serum Sickness in Rabbits

This experiment takes the apute experimental serum sickness (AESS) in rabbits as an animal model to investigate the mechanism of the regulatory effects of Dexamethasone (DX) . The results show. DX doesn't inhibit the production of anti-BSA antibody but induces the tendency to increase the level of antibody in rabbits with DX administration on early days (EL, EH); immune complexes(BSA - anti-BSA IGg, CIC) in the rabbits of EL and EH are significantly increased comparing with the later days (LE, LH) and positive controls. Non-specific esterase stainings and the pathological changes of kidney sections are markedly lessened though the amount of anti - BSA antibody, circulating immune complex (CIC) and superoxides dismutase activity in the rabbits of LE and L H are the same as the positive control. The outcome of protecting kidneys of AESS rabbits from injury by DX administration . probadly results from the effects of that DX inhibits infiltration of monocytes into the glomeruli. The role of oxygen radicals in AESS needs further investigation.