血管内皮生长因子在宫颈癌组织中的表达及与临床病理因素的关系

目的 探讨宫颈癌组织中血管内皮生长因子（VEGF）的表达及与临床病理因素的关系.方法 应用免疫组织化学S-P方法检测10例正常宫颈（NCE）,18例宫颈上皮内瘤样病变（CIN）,77例宫颈癌（ICC）组织中VEGF的表达情况.结果 VEGF蛋白在NCE,CIN,ICC中VEGF阳性表达率分别是10.0%（1/10）、44.4%（8/18）、74.0%（57/77）,三组间阳性表达率两两比较差异有统计学意义（P＜0.05）.VEGF蛋白表达与临床期别,组织学类型、间质浸润等无关,与细胞分化程度、脉管有无浸润、淋巴结转移有关.结论 VEGF蛋白表达水平与宫颈癌的进展及肿瘤细胞的去分化程度,脉管浸润,淋巴结转移正相关.宫颈癌组织中VEGF蛋白通过诱导血管生成,促进了宫颈癌的发生发展.

Expression of VEGF and its correlation with clinicopathological factors of cervical carcinoma ABSTRACT

Objective This study was designed to examine the expression of VEGF and its correlation with clinicopathological factors of cervical carcinoma. Methods mmunohistochemistry S-P method was used to detect the expression of VEGF in 10 cases of nomal cevical epithelium( NCE), 18 cases of cervical intraepithelial neoplasm (CIN) and 77 cases of early invasive carcinoma of cervix (ICC). Results The positive rate of VEGF protein in NCE,CIN,ICC was 10% (1/10) ,44.4% (8/18) ,74. 0% (57/77), respectively. The defference was significant (P ＜0. 05). Expresson of VEGF was not related with tumor stage, histologic types and stroma infiltration, but related with cell differentiation and intravascular involvement、lymph node metastasis. Conclusion VEGF protein had a positive correlation with cell differentiation and intravascular involvement 、 lymph node metastasis. the expression of VEGF gene result in the occurrence and development of cervical carcinoma by inducing the angiogenesis.