Epigenetic control of the basal-like gene expression profile via Interleukin-6 in breast cancer cells |
| |
| Authors: | Laura D'Anello Pasquale Sansone Gianluca Storci Valentina Mitrugno Gabriele D'Uva Pasquale Chieco Massimiliano Bonafé |
| |
| Institution: | 1.Center for Applied Biomedical Research (CRBA),St. Orsola-Malpighi University Hospital,Bologna,Italy;2.Department of Experimental Pathology,University of Bologna,Bologna,Italy;3.Department of Pharmacology and Toxicology,University of Bologna,Bologna,Italy |
| |
| Abstract: | Background Basal-like carcinoma are aggressive breast cancers that frequently carry p53 inactivating mutations, lack estrogen receptor-α
(ERα) and express the cancer stem cell markers CD133 and CD44. These tumors also over-express Interleukin 6 (IL-6), a pro-inflammatory
cytokine that stimulates the growth of breast cancer stem/progenitor cells. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
