糖耐康颗粒干预糖尿病患者前期糖耐量异常临床观察

目的：糖调节受损阶段是糖尿病发生过程的必经阶段，在不经干预的前提下，有近四分之一到患者在4-7年内发展为糖尿病。因此，对糖尿病前期的干预治疗在糖尿病预防与控制方面具有重要意义。本研究主要考察糖耐康颗粒对2 型糖尿病前期的疗效。方法：记录入组糖尿病前期患者年龄、病程、性别、中医症状积分等，检测病人血脂、血糖、肝肾功能、心电图等，在低糖低盐饮食及合理运动的健康宣教的情况下，以随机数字表法分为对照组31例与治疗组43例，以双盲给药，分别以模拟糖耐康安慰剂颗粒与糖耐康颗粒治疗气阴两虚型2 型糖尿病前期患者74例，疗程为3 个月。3 个月后检测空腹及餐后血糖，糖化血红蛋白，糖耐量，胰岛素耐量等指标考察二者疗效。结果：糖耐康颗粒无论在患者治疗有效率、中医症状积分及血糖复常率方面均优于安慰剂，且服用糖耐康颗粒物无肝肾功能等损伤。结论：糖耐康对糖尿病前期患者治疗安全有效。

Tangnaikang Granule Intervention in Diabetic Patients with Early Clinical Observation of Abnormality of Glucose Tolerance

The stage of impaired glucose regulation is a necessary stage in the development of diabetes.Nearly a quarter of patients without diabetes intervention develop into diabetes within four to seven years without intervention.Therefore,the intervention of pre-diabetes treatment in the prevention and control of diabetes is of great significance.This study was to investigate the effect of Tangnaikang granule at the early stage of type 2 diabetes mellitus.The age,course of disease,sex,symptom score of TCM were recorded,so were the blood lipid,blood glucose,liver and kidney function,electrocardiogram were recorded.Under the condition of low sugar and low salt diet and healthy exercise,the patients were divided into the control group(n=31)and the treatment group(n=43).The patients in the double-blind control group were treated with Kangnaikang granule and Tangnaikang granule to treat 74 patients with type 2 diabetes mellitus three months.Three months after the detection of fasting and postprandial blood glucose,glycosylated hemoglobin,glucose toler ance,insulin tolerance and other indicators to examine the efficacy of both.Tangnaikang granules were superior to placebo in terms of effective rate of treatment,TCM symptom score and blood sugar recovery rate,and taking Tangnaikang granule without liver and kidney function and other injuries.Tangnaikang is safe and effective for pre-diabetes patients.