Acute myeloid leukemia with t(5;18)(q35;q21). |
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| Authors: | E S Wang P Maslak K Cathcart J G Jurcic |
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| Affiliation: | Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center and Weill Medical College of Cornell University, 1275 York Avenue, New York, NY 10021, USA. wange@mskcc.org |
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| Abstract: | A case of acute myelocytic leukemia with a translocation (5;18)(q35;q21) is reported. Cytogenetic abnormalities of the long arm of chromosome 5 have long been known to affect hematopoiesis. Although translocations between 5q and other chromosomes have been associated with malignancy, this is the first reported case of a t(5;18) resulting in acute myeloid leukemia. Possible molecular mechanisms underlying the pathogenesis of the disease are discussed. |
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