| 吐温-80不同浓度对依普黄酮胶囊溶出度的影响 |
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| 引用本文： | 朱海涛,黄良永,陈吉炎,王章元,王振芬. 吐温-80不同浓度对依普黄酮胶囊溶出度的影响[J]. 中国药房, 2006, 17(3): 216-217 |
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| 作者姓名： | 朱海涛 黄良永 陈吉炎 王章元 王振芬 |
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| 作者单位： | 1. 湖北郧阳医学院附属太和医院,十堰市,442000
2. 华中科技大学同济医学院药学院,武汉市,430030 |
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| 摘 要： | 目的考察吐温-80不同浓度对依普黄酮胶囊溶出度的影响。方法分别配制含不同浓度吐温-80的依普黄酮胶囊,采用紫外分光光度法等测定依普黄酮的含量及溶出度,计算参数Td、T50、m,并对T50、Td值进行两两比较。结果吐温-80浓度在1%~3%范围内,随其浓度增加,T50、Td值均减小,其最佳浓度为2.5%。结论制剂时适量加入吐温-80可明显增加依普黄酮的溶出度(P<0.01)。
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| 关 键 词： | 依普黄酮 吐温-80 溶出度 紫外分光光度法 |
| 文章编号： | 1001-0408(2006)03-0216-02 |
| 收稿时间： | 2005-01-07 |
| 修稿时间： | 2005-03-08 |
Effects of Different Concentrations of Tween-80 on Dissolution of Ipriflavone Capsules |
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| ZHU Haitao,HUANG Liangyong,CHEN Jiyan,WANG Zhangyuan,WANG Zhenfen. Effects of Different Concentrations of Tween-80 on Dissolution of Ipriflavone Capsules[J]. China Pharmacy, 2006, 17(3): 216-217 |
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| Authors: | ZHU Haitao HUANG Liangyong CHEN Jiyan WANG Zhangyuan WANG Zhenfen |
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| Affiliation: | 1.The Affiliated Taihe Hospital, Hubei Provincial Yunyang Medical College,Shiyan 442000, China;2.College of Pharmacy,Tongji Medical College of Central China University of Science and Technology ,Wuhan 430030, China |
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| Abstract: | OBJECTIVE:To study the effect of tween-80at different concentrations on the dissolution of ipriflavone capsules.METHODS:Different concentrations of tween-80ipriflavone capsules were prepared with contents and dissolutions of ipriflavone capsules determined by UV spectrophotometry,parameter values of T d ,T 50 and m were calculated and compared among each other.RESULTS:When tween-80were at a concentration range of1%～3%,the T 50 and T d diminished with the increase of concentration of tween-80,its optimal concentration was2.5%.CONCLUSION:The dissolution of ipriflavone capsules can be markedly increased if the preparation was added with optimal amount of tween-80(P<0.01). |
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| Keywords: | Ipriflavone Tween 80 Dissolution Ultrav |
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