脑卒中供者心脏的心肌损伤机制与临床研究进展

脑死亡供者心脏是目前心脏移植最主要的器官来源。脑死亡发生后会出现严重的血流动力学改变和一系列器官功能变化，进而造成组织器官的功能损害甚至丧失，尤其是心脏。神经系统和心血管系统的生理、病理生理之间存在密切联系和相互作用，脑卒中发生后，通过脑-心轴反应导致自主神经失调、神经内分泌紊乱和强烈而持续的炎症反应，引发交感风暴、儿茶酚胺风暴、炎症风暴等导致脑卒中所致心脏损伤。本文旨在对近年来有关脑卒中供者心脏心肌损伤的机制研究及其对心脏移植术后疗效和预后影响的相关研究进行综述，为临床实践和进一步研究提供参考。

Clinical research progress and mechanism on myocardial injury in hearts from donors with stroke

At present, the heart of donor from donation after brain death are the primary organ sources for heart transplantation. After brain death, severe hemodynamic changes and a series of organ functional changes will occur, thereby leading to the functional damage or even loss of tissues and organs, especially the heart. Intimate relationship and interaction have been found in the physiology and pathophysiology between nervous and cardiovascular systems. After stroke, autonomic nervous disorder, neuroendocrine disorder and intense and persistent inflammatory reaction could be caused by the brain-heart axis reaction, leading to stroke-induced cardiac injuries, such as sympathetic storm, catecholamine storm, inflammatory storm, etc. In this article, research progresses on the mechanism of myocardial injury in heart from donors with stroke and the effect on clinical efficacy and prognosis after heart transplantation were reviewed, aiming to provide reference for clinical practice and subsequent research.