小鼠成纤维细胞中PLC水解肌醇磷脂的数学模型

目的:构建小鼠成纤维细胞中磷脂酶C水解肌醇磷脂的数学模型. 方法:以细胞实际信号传递过程为基础、以准稳态近似为原则,利用微分方程建立数学模型模拟肌醇磷脂的代谢过程. 结果:建立了一磷酸肌醇和表皮生长因子受体间浓度关系的微分方程,并以此来描述肌醇磷脂的水解速度. 结论:本数学模型描述了肌醇磷脂代谢的生物学特征以及主要产物间的浓度依赖关系,讨论了各个参数对肌醇磷脂代谢的数学模型的影响,分析了磷酸肌醇3激酶和Ras/细胞外信号调节激酶对肌醇磷脂的消耗.

A mathematical model of inositol phospholipid hydrolyzed by PLC in mouse fibroblasts

AIM: To establish a mathematical model of inositol phospholipid hydrolyzed by phospholipase C in mouse fibroblasts. MEHTODS: Based on the cellular signal transduction and the Law of the Quasi Steady State Approximation, the metabolizability of inositol phospholipid was simulated by making use of mathematical model of differential equations. RESULTS: Differential equations of concentration relations were formulated between inositol phosphate and epidermal growth factor receptor, and the hydrolysable rate was demonstrated in these differential equations. CONCLUSION: This mathematical model describes the biological characteristics and the concentration relations between the key products during the hydrolyzation of inositol phospholipid. The effect of parameters on the mathematical model has been discussed and the consumption of inositol phospholipid by Ras/extracellular signal regulated kinase and phosphatidylinositol 3 kinase pathways has been analyzed.