硫酸卷曲霉素超声雾化吸入联合抗结核药物治疗复治菌阳肺结核的近期疗效观察

目的评价硫酸卷曲霉素(CPM)超声雾化吸入联合抗结核药物治疗复治菌阳肺结核的疗效。方法126例复治菌阳肺结核患者随机分为治疗组和对照组，2组均予以合理抗结核化疗方案，治疗组加用卷曲霉素超声雾化吸入治疗。结果经过3个月的治疗，治疗组的痰菌阴转率为82.5%，肺部病变吸收总有效率为93.7%,空洞闭合或缩小的总有效率为93.7%;对照组的痰菌阴转率为61.9%,肺部病变吸收总有效率为73.0%,空洞变化总有效率为80.9%;治疗组明显优于对照组，差异有统计学意义（P＜0.01）。结论并用卷曲霉素超声雾化吸入治疗复治菌阳肺结核疗效优于对照组，值得进一步研究。

Clinical observation of the therapeutic effect with capreomycin ultrasonic aerosol inhalation combined with antitubercular agents in the treatment of retreated sputum positive pulmonary tuberculosis

Objective To evaluate the therapeutic effect of capreomycin（CPM） ultrasound aerosol inhalation spray combined with antitubercular agents in the treatment of retreated sputum positive pulmonary tuberculosis. Methods 126 retreated patients with sputum positive for AFB were randomly divided into two groups. CPM aerosolization combined with rational chemotherapy was given in the treatment group, and chemotherapy only for the control group. Results After 3 months of treatment, the rate of sputum negative conversion and radiological improvement of pa- tients in the treatment group were 82.5% and 93.7% respectively,much higher than those of the control group （73.0% and 80. 9% respectively）. There are statistically significant differences between two groups respectively （P〈0. 01）. Conclusions Our study showed that antitubercular agents combined with CPM ultrasonic aerosolization had higher efficacy than chemotherapy alone. It needs to be studied further.