番茄红素在血液透析患者中的抗氧化及调脂作用

目的观察番茄红素(Lyc)在接受静脉铁剂治疗的维持性血液透析(MHD)患者中的抗氧化及调脂作用。方法选取30例MHD患者,随机分为2组(对照组和试验组,各15例)。对照组(C)在患者透析时给予蔗糖铁注射液100 mg,2次/周,用药5 w(补铁量为1000 mg),观察时间8 w。试验组(L):除蔗糖铁注射液使用如上述外,同时再口服Lyc胶囊,2粒/次,2次/日,用药8 w,观察时间8 w。观察并比较两组患者治疗前及治疗8w后的氧化指标和血脂水平。结果两组患者治疗后SOD和GSH-Px水平较治疗前有显著性下降;治疗后L组SOD和GSH-Px水平显著性高于C组。两组患者治疗后MDA水平较治疗前有显著性升高;治疗后L组MDA水平显著性低于C组。治疗后L组HDL较治疗前有显著性升高,LDL/HDL比值较治疗前有显著性下降。结论番茄红素在接受静脉铁剂治疗的MHD患者中,可以起到抗氧化的作用,同时可以升高HDL水平,降低LDL/HDL比值。

EFFECTS OF LYCOPENE ON OXIDATIVE STRESS AND BLOOD LIPID IN MAINTENANCE HEMODIALYSIS PATIENTS

Objective To investigate the effects of lycopene(Lyc) on oxdative stress and blood lipid in maintenance hemodialysis(MHD) patients receiving intravenous iron therapy.Method Thirty MHD patients were enrolled and randomly divided into two groups: control group(C group,n=15) and Lyc treated group(L group,n=15).In C group,the patients were treated with iron sucrose,100 mg i.v.,during 10 consecutive hemodialysis sessions,twice a week for 5 w.The total supplement amount was 1000 mg.In L group,in addition to intravenous iron sucrose,the patients were given orally Lyc 2 tablets twice daily for 8 w.Their redox markers and blood lipid levels were measured before and after treatment.Results Compared with the pre-treatment,serum SOD and GSH-Px in both groups were decreased and serum MDA elevated significantly.Serum SOD and GSH-Px were higher and serum MDA lower in C group than those in L group after treatment.HDL was elevated and the ratio of LDL/HDL decreased significantly in L group after treatment.Conclusion Lycopene can inhibit oxidative stress induced by intravenous iron sucrose in MHD patients.Meanwhile it can increase the level of HDL and decrease the ratio of LDL/HDL.