胸腔置管联合透明质酸钠防治结核性胸膜炎胸膜肥厚：成本效果分析

目的探索防治结核性胸膜炎胸膜肥厚成本低、效果好的治疗方法。方法64例中至大量游离结核性胸腔积液患者随机分为治疗组和对照组。治疗组胸腔置管完全引流积液后注入透明质酸钠，对照组常规胸穿抽液。统计治疗3个月后2组花费的成本，进行成本效果分析及敏感度分析。 结果59例患者参与最后结果分析。治疗3个月后治疗组、对照组胸膜肥厚发生率是6.7%、31.0%（有效率分别是：93.3%、69.0%）（P＜0.05）；成本效果比（C/E）是35.19，47.53，敏感度分析显示C/E 35.63，49.00。结论胸腔置管联合透明质酸钠防治结核性胸膜炎胸膜肥厚是成本低、效果好的方法。

Intrathoracic cannula combining with sodium hyaluronate to prevent pleural thickening of tuberculous pleurisy: cost/effective analysis

Objective To explore the method of lower cost and better results, to prevent pleural thiekening(PT) of tuberculous pleurisy. Methods Sixty-four patients with middle to large pleru-ral effusions were randomly assigned to a treatment group and a control group. Patients in treat-ment group given with sodium hyaluronate via central venous catheter into the thoracic cavity after pleural effusion was drainaged completely,while patients in control group received routine thoraeen-tesis. We calculated the cost after 3 months in two groups respectively and analyzed the cost-effec-tiveness and sensitivity. Results Fifty-nine patients were available for final analysis. The inci-dence rate of PT at 3rd month were 6.7% in treatment group and 31.0% in control group(the effec-tive rate: 93.3% vs. 69.0%, respectively) with statistically significant difference(P<0.05) ; The cost/effective rate were 35.2 in the treatment group and 47. 5 in the control group. Sensitivity anal-ysis showed 35.6 in the treatment group and 49.00 in the control group. Conclusions Intrathorac-ic cannula combining with administration of sodium hyaluronate is a method of lower cost and better results to prevent pleural thickening of tuberculous pleurisy.