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| 内皮祖细胞移植治疗糖尿病大鼠下肢动脉缺血的动脉造影改变 | |
| 引用本文： | 王宁,张明琛,姜涛,段明军,谢自敬.内皮祖细胞移植治疗糖尿病大鼠下肢动脉缺血的动脉造影改变[J].新疆医科大学学报,2011,34(1). |
| 作者姓名： | 王宁 张明琛 姜涛 段明军 谢自敬 |
| 作者单位： | 1. 新疆医科大学第一附属医院,干内一科,新疆,乌鲁木齐,830011 2. 新疆医科大学第一附属医院,内分泌科,新疆,乌鲁木齐,830011 3. 新疆医科大学第一附属医院,试验动物中心,新疆,乌鲁木齐,830011 |
| 摘 要： | 目的 对比观察内皮祖细胞(EPCs)和骨髓单个核细胞移植治疗糖尿病大鼠下肢动脉缺血的动脉变化.方法 将雄性Wistar大鼠30只诱导成糖尿病模型,其中25只成模,成模鼠结扎左下肢股动脉制造下肢缺血模型,此后随机分成3组,分别给于生理盐水(A组,n=7),内皮祖细胞(B组,n=9),骨髓单个核细胞(C组,n=9),沿股动脉走向、多点肌肉注射.继续喂养28 d后行下肢动脉造影检测下肢血流.结果 动脉造影结果显示EPCs移植治疗组缺血侧下肢动脉显影血管数多于对照组(P<0.05); EPCs移植治疗组血管数多于骨髓间充质干细胞移植治疗组,但无统计学差异.结论 EPCs移植治疗对糖尿病大鼠下肢缺血效果明确. |
| 关 键 词： | 内皮祖细胞 糖尿病 大鼠模型 下肢缺血 移植 |
Angiogenesis observed by angiography in endothelial progenitor cells transplantation to hindlimb ischemia rat model with diabetes |
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| WANG Ning,ZHANG Ming-chen,JIANG Tao,et al.Angiogenesis observed by angiography in endothelial progenitor cells transplantation to hindlimb ischemia rat model with diabetes[J].Journal of Xinjiang Medical University,2011,34(1). | |
| Authors: | WANG Ning ZHANG Ming-chen JIANG Tao |
| Institution: | WANG Ning,ZHANG Ming-chen,JIANG Tao,et al(Department of the No.1 cadre wards medicine,First Affiliated Hospital,Xinjiang Medical University,Urumqi 830011,China) |
| Abstract: | Objective To compare the effects of transplantation of endothelial progenitor cells(EPCs) and bone marrow mononuclear cell on hind limb ischemia in diabetic rat model.Methods The male STZ-induced diabetes Wistar rats model were randomly divided into 3 groups: Sodium Chloride control group(A group),EPCs transplantation group(B group) and bone marrow mononuclear cell group(C group),each group had 9 mouse.Rats with hind limb ischemia were treated by transplantation of ex vivo expanded EPCs and bone marrow mono... |
| Keywords: | endothelial progenitor cells diabetes rat model hindlimb ischemia transplantation |
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