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| 中医引经药葛根对食管癌细胞系TE-1及ECA109AQP1mRNA表达的影响 | |
| 引用本文： | 姜孝芳,李卉,李秀梅,陈艳,史红,马莉莉,古丽努尔,李惠武. 中医引经药葛根对食管癌细胞系TE-1及ECA109AQP1mRNA表达的影响[J]. 新疆医科大学学报, 2011, 34(3) |
| 作者姓名： | 姜孝芳 李卉 李秀梅 陈艳 史红 马莉莉 古丽努尔 李惠武 |
| 作者单位： | 1. 新疆医科大学基础医学院科研中心,新疆,乌鲁木齐,830011 2. 新疆医科大学基础医学院形态中心,新疆,乌鲁木齐,830011 3. 新疆医科大学基础医学院生物化学与分子生物学教研室,新疆,乌鲁木齐,830011 4. 新疆医科大学中医学院,新疆,乌鲁木齐,830011 |
| 摘 要： | 目的 探讨中医引经药葛根对食管癌细胞系TE-1及ECA109 AQP1 mRNA表达的影响.方法 以5 g/L及10 g/L的葛根素注射液干预食管癌细胞系TE-1及ECA109,干预24 h后用逆转录聚合酶链反应(RT-PCR)检测AQP1 mRNA表达,观察表达结果.结果 AQP1在食管癌细胞系ECA109及TE-1中均有少量表达;葛根素可上调ECA109及TE-1细胞系AQP1表达.结论 葛根素通过上调AQP1 mRNA的表达,从而影响食管癌细胞水转运. |
| 关 键 词： | 食管癌 葛根素 引经 |
Effect of puerarin on AQP1 mRNA expression level in esophageal cancer cell line TE-1 and ECA109 |
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| JIANG Xiao-fang,LI Hui,LI Xiu-mei,et al. Effect of puerarin on AQP1 mRNA expression level in esophageal cancer cell line TE-1 and ECA109[J]. Journal of Xinjiang Medical University, 2011, 34(3) | |
| Authors: | JIANG Xiao-fang LI Hui LI Xiu-mei et al |
| Affiliation: | JIANG Xiao-fang,LI Hui,LI Xiu-mei,et al(Department of Science Research Center,Preclinical Medicine,Xinjiang Medical University,Urumqi 830011,China) |
| Abstract: | Objective To investigate the effect of puerarin on aquaporin(AQP)1 mRNA expression level in esophageal cancer cell line TE-1 and ECA109.Methods Esophageal cancer cell line TE-1 and ECA109 were treated by puerarin injection with 5 g/L and 10 g/L.Then the AQP1 mRNA expression level were detected by RT-PCR after 24 hours.Results There was little expression of AQP1 in esophageal cancer cell line TE-1 and ECA109.Puerarin up regulated the APQP1 expression level in TE-1 and ECA109.Conclusion Puerarin may play an i... |
| Keywords: | AQP1 |
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