人工肝支持系统治疗重症药物性肝损伤43例

目的：观察人工肝支持系统治疗重症药物性肝损伤的疗效。方法：2003-012008-01我院住院诊治的43例重症药物性肝损伤病例,分为人工肝治疗组和对照组,观察两组治疗前后肝功能变化,比较平均住院日、病死率。结果：治疗组治疗前后ALT、TBIL、PTA有显著差异（P均〈0.01）,对照组治疗前后差异亦具显著性（P均〈0.05）;治疗后组间对照,ALT下降无差异（P〉0.05）,治疗组TBIL下降明显（P〈0.05）,PTA水平显著升高（P〈0.05）。治疗组平均住院日47.5 d,病死率24.1%,对照组平均住院日34.7 d,病死率57.1%,两组病死率比较差异显著（P〈0.05）。结论：与常规内科治疗相比较,人工肝可显著改善重症药物性肝损伤患者的肝功能,降低死亡率。

Treatment of 43 cases of drug-induced liver injuries with artificial liver support system

Objective：To investigate the curative effect of artificial liver support system on the patients with severe drug-induced liver injury（DILI）.Methods：A total of 43 inpatients from Jan.2003 to Jan.2008 were included and divided into artificial liver group and control group.The liver functions before and after treatment,mean hospitalized time and mortality were compared between the two groups.Results：There were significant differences before and after treatment in both groups in ALT,TBil,and PTA（P﹤0.05 or P﹤0.01）.The TBil level decreased and PTA level increased significantly in the experimental group compared to the control group（P﹤0.05）.The mean hospital stay was 47.5 d and 34.7 d respectively,and the mortality was 24.1% and 57.1% respectively（P﹤0.05）.Conclusion：Artificial liver support system significantly improve liver function and decrease mortality of the patients with severe DILI.