心包脂肪组织体积与冠状动脉斑块组成的相关性研究

目的：本研究的目的是评估心包脂肪组织（PAT）体积与320排冠状动脉CT造影（CCTA）动脉硬化斑块组成的关系。方法本研究纳入1597例因可疑冠心病而接受320排 CCTA 检查的患者（男1090例，女507例，年龄35～71岁）。其中382例发现存在动脉斑块。我们比较了冠心病和斑块组成存在斑块、钙化斑块（CP）、非钙化斑块（NCP）、混合斑块（MP）、多支病变和梗阻性狭窄]与无冠心病者的PAT体积。结果单因素分析显示存在CP、NCP、MP及多支血管病变者的PAT体积大于无斑块者分别为（211.4±93.6）cm3、（233.2±95.0）cm3、（257.3±82.1）cm3及（261.5±101.7）cm3 vs.（173.7±98.1） cm3，P值分别为0.012、0.008、0.004及0.002]。存在梗阻性狭窄者的PAT体积明显大于无斑块者（279.2±99.81）cm3 vs.（173.7±98.1）cm3，P＜0.001]。在多因素Cox比例风险回归模型分析中，只有MP、多支血管病变和梗阻性狭窄者的PAT体积明显大于无斑块者（P＜0.001）。结论存在冠状动脉斑块、CP、NCP、MP、多支血管病变和梗阻性狭窄患者的PAT体积大于无斑块者，PAT体积是冠心病重要的危险因素之一。

Pericardial adipose tissue and coronary atherosclerotic plaque composition on 320-raw coronary computed tomography angiography

Objective To assess the relationship between pericardial adipose tissue （PAT） volume and plaques composition of coronary artery detected by 320-rows coronary computed tomography angiography （CCTA）. Methods This study consisted of 1597 consecutive patients who underwent 320-raw CCTA examination for the evaluation of suspicious coronary artery disease（including 1090 men and 507 women; age range, 18-55 years）. Of which 382 cases were found arterial plaques.We compared PAT volume in patients with coronary atherosclerotic plaquespresence plaque, calcified plaque（CP）, non-calcified plaque（NCP）, mixed plaque （MP）, mukivessels lesions, and obstructive stenosis] and without coronary atherosclerotic plaques. Results Univariate analysis showed the PAT volume in patients with presence of CP, NCP, MP and multi-vessel disease larger than those without plaques respectively （211.4 ± 93.6）cm3, （233.2 ±95）cm3, （257.3 ± 82.1）cm3 and （261.5±101.7）cm3 vs. （173.7±98.1）cm3, P=0.012, 0.008, 0.004, 0.002] and the PAT volume in patients with presence of obstructive stenosis was significantly larger than those without plaques（279.2 ± 99.81）cm3 vs. （173.7 ±98.1）cm3, P〈 0.001]. In multivariate Cox proportional hazards regression analysis, only the PAT volume in patients with MP, multivessel disease and obstructive stenosis was significantly higher than those without plaques（P〈0.001）. Conclusion The PAT volume in patients with presence of coronary plaques, CP, NCP, MP, multivessel disease and obstructive stenosis greater than those without plaque, PAT volume is an important risk factor for coronary heart disease.