| Apelin与糖尿病及其血管并发症相关性研究进展 |
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| 引用本文： | 陈薇,赵晓娟,王楠楠.Apelin与糖尿病及其血管并发症相关性研究进展[J].中华临床医师杂志(电子版),2013(24):314-316. |
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| 作者姓名： | 陈薇 赵晓娟 王楠楠 |
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| 作者单位： | 中国医科大学附属第一医院内分泌科,沈阳110010 |
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| 基金项目： | 辽宁省科学技术计划项目（2009225010-10） |
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| 摘 要： | 胰岛功能缺陷与胰岛素抵抗是2型糖尿病发病的两个关键因素。近年研究认为，氧化应激、炎症反应与脂肪内分泌相互作用，从而引起胰岛素抵抗和β细胞功能障碍。因此，对上述机制进行干预成为实验研究及临床治疗的一个热点。脂肪因子Apelin具有影响胰岛素敏感性、影响心血管功能、抗炎及抗氧化应激等作用。本文就Apelin与糖尿病、糖尿病血管并发症的关系展开综述。
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| 关 键 词： | 糖尿病 糖尿病肾病 糖尿病视网膜病变 高血压 冠心病 Apelin |
The correlation of Apelin with diabetes,diabetes complications,and its eomorbid disease |
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| CHEN Wei,ZHAO Xiao-juan,WANG Nan-nan.The correlation of Apelin with diabetes,diabetes complications,and its eomorbid disease[J].Chinese Journal of Clinicians(Electronic Version),2013(24):314-316. |
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| Authors: | CHEN Wei ZHAO Xiao-juan WANG Nan-nan |
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| Institution: | .( Department of Endocrinology, the First Affiliated Hospital, China Medical University, Shenyang 110010, China) |
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| Abstract: | Islet B cell function defect and insulin resistance are two key factors for type 2 diabetes. Recent studies suggest that the interaction of oxidative stress, inflammation, and fat endocrine cause insulin resistance and beta cell dysfunction. Therefore, the intervention of above mechanism become a focus in the experimental study and clinical treatment. The fat factor--Apelin influences insulin sensitivity and cardiovascular function, anti-inflammatory and anti-oxidative stress, and so on. The relationship between Apelin and diabetes, vascular complications of diabetes were summarized in this review. |
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| Keywords: | Diabetes mellitus Diabetic nephropathies Diabetic retinopathy Hypertension Coronary disease Apelin |
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