| 胰高血糖素样肽-1的生理作用及分泌调节因素 |
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| 引用本文： | 许建萍,肖新华. 胰高血糖素样肽-1的生理作用及分泌调节因素[J]. 中华临床医师杂志(电子版), 2013, 0(24): 302-304 |
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| 作者姓名： | 许建萍 肖新华 |
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| 作者单位： | 中国医学科学院 北京协和医学院 北京协和医院内分泌科 卫生部内分泌重点实验室, 北京100730 |
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| 基金项目： | 国家自然科学基金（81170736） |
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| 摘 要： | 胰高血糖素样肽-1（GLP-1）是于进食后由肠道L细胞释放的一种胃肠道激素。咀嚼行为本身可能刺激GLP-1的分泌。该激素可增强葡萄糖依赖的胰岛素合成和分泌，同时抑制胰高糖素的分泌，延缓胃排空。并且可以刺激β细胞再生和增殖。GLP-1可以通过迷走神经作用于下丘脑的受体起到控制食欲和增强饱感的作用。GLP-1还可以对神经系统和心血管系统起到保护作用。
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| 关 键 词： | 胰高血糖素样肽1 咀嚼 |
Physiology function of GLP-1 and its regulation factor of secretion |
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| XU Jian-ping,XIAO Xin-hua. Physiology function of GLP-1 and its regulation factor of secretion[J]. Chinese Journal of Clinicians(Electronic Version), 2013, 0(24): 302-304 |
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| Authors: | XU Jian-ping XIAO Xin-hua |
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| Affiliation: | . Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100730, China) |
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| Abstract: | GLP-1 is a gut hormone which is secreted by intestinal endocrine L cells in response to ingested nutrients. Chewing can stimulate secretion of GLP-1. GLP-1 regulates glucose levels by stimulating glucose-dependent insulin secretion and biosynthesis, and by suppressing glucagon secretion, delaying gastric emptying. GLP-1 also increases beta cell proliferation and neogenesis. GLP-1 can control appetite and enhance satiety and fullness through vague to hypothalamic GLP-1 receptor. GLP-1 can also protect neuron system and cardiovascular system. |
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| Keywords: | Glucagon-like peptide 1 Mastication |
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