小剂量阿托伐他汀治疗高龄动脉硬化的临床效果及安全性观察

目的探讨小剂量阿托伐他汀治疗高龄动脉硬化患者的临床疗效及安全性。方法将我院心血管内科收治的高龄动脉硬化患者共62例随机分为观察组和对照组，对照组患者采用常规方案治疗原发疾病，观察组患者在同对照组治疗的基础上加用阿托伐他汀钙片治疗，比较两组患者治疗前后血脂及脉搏波传导速度的变化，治疗期间心脑血管事件及药物不良反应发生率。结果治疗后观察组患者脉搏波传导速度较治疗前明显下降（P〈0．05），LDL—c及TC较治疗前明显降低（P〈0．05）。治疗后观察组患者脉搏波传导速度、LDL—C及Tc均明显低于对照组（P〈0．05）；观察组心脑血管事件发生率（6．45％）明显低于对照组（32．26％）（P〈0．05）。结论在常规治疗原发疾病的基础上加用阿托伐他汀钙治疗高龄动脉硬化患者，可显著减慢患者脉搏波传导速度，降低低密度脂蛋白及胆固醇水平，减少心血管事件发生率，不增加不良反应发生率，具有较好的临床疗效和安全性。

Observation of clinical effect and safety of small-dose atorvastatin on elderly patients with arteriosclerosis

Objective To investigate the therapeutic effect and safety of small-dose atorvastatin on elderly patients with arteriosclerosis. Methods 62 elderly patients with arteriosclerosis in our hospital were randomly divided into observation group and control group. Routine treatment for primary disease was used in both groups. Additionally, small-dose atorvastatin was added in the observation group. Blood liquid and pulse wave velocity before and after treatment, cardiovascular events during treatment and the incidence of adverse drug reactions were compared between the two groups. Results In observation group, the pulse wave velocity, LDL-C and TC after treatment were all significantly lower than those before treatment （ P 〈 0.05 ） and those in the control group （P 〈 0.05）. The incidence of cardio cerebral vascular events in the observation group （6.45%） was significantly lower than that in the control group （32.26%） （P 〈 0.05）. Conclusion The routine therapy plus atorvastatin statins in treating elderly patients with arteriosclerosis can greatly reduce pulse wave velocity, density lipoprotein, cholesterol level, and the incidence of cardiovascular events. This combined therapy does not increase the incidence of adverse reactions, which is effective and safe.