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Prognostic significance of adhesion molecules (sICAM-1, sVCAM-1) and VEGF in colorectal cancer patients
Authors:Dymicka-Piekarska Violetta  Guzinska-Ustymowicz Katarzyna  Kuklinski Adam  Kemona Halina
Affiliation:
  • a Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Poland
  • b Department of General Pathomorphology, Medical University of Bialystok, Poland
  • c Department of General and Gastroenterological Surgery, Medical University of Bialystok, Poland
    		•
    Abstract:

    Introduction

    Adhesion molecules take part in the interaction between host cells and cancer cells. In the current study the relationship between the soluble adhesion molecules sICAM-1 and sVCAM-1 and proangiogenic factor VEGF in colorectal cancer progression were measured.

    Materials and methods

    The study group consisted of 46 patients with colorectal carcinoma (classified due to TNM classification) and 40 controls. sICAM-1, sVCAM-1 and VEGF plasma concentration were measured by enzyme-linked immunosorbent assay (ELISA).

    Results

    All measured parameters levels were increased significantly in patients with colorectal cancer in comparison to controls (p < 0.001). sICAM-1, sVCAM-1 and VEGF increased significantly due to colorectal cancer progression. There was a positive correlation between sICAM-1 and sVCAM-1 in all study groups.

    Conclusions

    Our results demonstrated in CRC patients significantly increased levels of soluble adhesion molecules (VCAM-1 and sICAM-1) and angiogenic factor (VEGF) as compared to control group. The dynamics of these molecules showed the growing tendency along with tumor size and metastasis formation.
    Keywords:CAM, cell adhesion molecules   ICAM, intercellular adhesion molecule   VCAM, vascular cell adhesion molecule   VEGF, vascular endothelial growth factor   CRC, colorectal cancer
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