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| 依托咪酯的遗忘作用及其与γ-氨基丁酸A型受体的关系 | |
| 引用本文： | 乔微,周华,裴美兰,汤红芳,唐钢,程伟. 依托咪酯的遗忘作用及其与γ-氨基丁酸A型受体的关系[J]. 南通医学院学报, 2009, 29(4) |
| 作者姓名： | 乔微 周华 裴美兰 汤红芳 唐钢 程伟 |
| 作者单位： | 1. 江苏省南通市妇幼保健院麻醉科,南通,226006 2. 淮安市第一人民医院麻醉科 3. 徐州医学院附属医院麻醉科 |
| 摘 要： | 目的:探讨依托咪酯(etomidiate,ET)的遗忘作用及其与GABAA受体的关系。方法:小鼠静脉注射(intravenous injection,iv)不同剂量的ET后,静脉注射不同剂量的GABAA受体阻断药一叶秋碱(securinine,Se)。在跳台和避暗实验中,分别观察跳台和避暗的潜伏期(latancy)及错误次数(number of errors)的变化。结果:ET能剂量依赖性地缩短跳台和避暗潜伏期、增加跳台和避暗错误次数;Se能部分拮抗以上作用。结论:ET可以产生遗忘作用,GABAA受体可能是ET遗忘作用的重要靶位。 |
| 关 键 词： | 依托咪酯 γ-氨基丁酸A型受体 遗忘 一叶秋碱 麻醉 小鼠 |
Relationship between GABAA receptor and the amnesic effects induced by etomidiate |
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| Affiliation: | QIAO Wei1; ZHOU Hua1; PEI Meilan1; et al (1Department of Anesthesiology; Maternal and Child Health Hospital of Nantong; Nantong 226006; 2 Department of Anesthesiology; the First Hospital of Huai'an; 3Department of Anesthesiology; Affiliated Hospital of Xuzhou Medical College); |
| Abstract: | Objective:To investigate the effect of GABAA receptor on the amnesia induced by etomidiate in mice. Methods:Etomidiate was intravenously (iv) injected and securinine,a GABAA receptor antagonist,was intravenously injected after the etomidiate injection. Then two techniques including stepthrough test and stepdown test were employed to evaluate the effects on the latency and the number of errors. Results:Etomidiate decreased the latency and increased the number of errors in conscious mice. Securinine can antag... |
| Keywords: | Etomidiate GABAA receptor Amnesia Securinine Anesthesia Mouse |
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