肾脏病病人红细胞免疫功能及sIL-2R水平的变化

①目的 了解肾脏病病人红细胞免疫功能和血清可溶性白细胞介素-2受体(sIL—2R)水平的变化。②方法 采用红细胞花环实验和双抗体夹心ELISA法,检测了53例肾脏病病人红细胞C_3b受体花环率(E-C_3bRR)、红细胞C_3b花环形成促进率(RFER)和抑制率(RFIR)、循环免疫复合物(CIC)、红细胞免疫复合物花环率(E-ICR)和sIL-2R水平的变化。③结果肾脏病病人E-C_3bRR,RFER明显低于对照组,而CIC,E-ICR,RFIR和sIL-2R明显高于对照组,差异均具有极显著性(t＝3.011~4.650,p均<0.01)。尿毒症病人以上各检测指标的变化较慢性肾炎病人更明显(t＝3.626~4.535,p均<0.001)。④结论肾脏病病人血清sIL—2R水平升高和红细胞免疫功能降低与其病情严重程度有关。

THE CHANGES OF ERYTHROCYTE IMMUNE FUNCTION AND SOLUBLE INTERLEUKIN 2 RECEPTOR IN PATIENTS WITH KIDNEY DISEASES

Objective To evaluate the changes of erythrocyte immune function and serum soluble interleukin 2 receptor (sIL-2R) level in patients with kidney diseases. Method By using erythrocyte rosette tests and double antibody sandwich ELISA methods, we measured the changes of erythrocyte C3b receptor rosette rate (E-C3bRR), erythrocyte C3b receptor rosette forming effective rate (RFER) , inhibitory rate (RFIR), circulation immune complex(CIC) , erythrocyte immune complex rosette rate(E-ICR) and sIL-2R in patients with kidney diseases. Result The E-C3bRR, RFER were significantly lower, and CIC, E-ICR, RFIR and sIL-2R were all significantly higher in the patients than in the controls(t = 3. 011~4- 650, P<0. 01). These variations in uremia patients were more obvious than in the nephritis patients (t = 3. 626~4. 535, P<0. 001). Conclusion The increase of sIL-2R level and the decrease of erythrocyte immune function may be related to the changes of kidney disease conditions.