| 紫杉醇联合顺铂治疗中晚期非小细胞肺癌34例分析 |
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| 引用本文： | 王洪亚,韩啸,王子安.紫杉醇联合顺铂治疗中晚期非小细胞肺癌34例分析[J].蚌埠医学院学报,2009,34(8):682-684. |
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| 作者姓名： | 王洪亚 韩啸 王子安 |
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| 作者单位： | 蚌埠医学院第一附属医院肿瘤内科, 安徽蚌埠 233004 |
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| 摘 要： | 目的:观察紫杉醇联合顺铂治疗中晚期非小细胞肺癌的近期疗效及毒副作用。方法:对34例中晚期非小细胞肺癌患者应用国产紫杉醇135 mg/m2,d1静脉滴注;顺铂75 mg/m2,d2~4静脉滴注,21天为1疗程,连用2个疗程。结果:34例均可评价疗效,总有效率(完全缓解+部分缓解)为41.2%。鳞癌和腺癌、Ⅲ期和Ⅳ期患者总有效率差异均无统计学意义(P>0.05),而初治患者总有效率高于复治患者(P<0.05)。毒副作用主要表现为骨髓抑制、脱发和关节肌肉疼痛,其他毒副作用较轻。结论:紫杉醇联合顺铂治疗中晚期非小细胞肺癌疗效较好,毒副作用可以耐受。
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| 关 键 词： | 肺肿瘤 肿瘤/药物疗法 癌 非小细胞肺 紫杉醇 顺铂 |
| 收稿时间： | 2009-02-13 |
A clinical study on paclitaxel plus cisplatin combined therapy in treatment of advanced non-small cell lung cancer |
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| WANG Hong-ya,HAN Xiao,WANG Zi-an.A clinical study on paclitaxel plus cisplatin combined therapy in treatment of advanced non-small cell lung cancer[J].Journal of Bengbu Medical College,2009,34(8):682-684. |
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| Authors: | WANG Hong-ya HAN Xiao WANG Zi-an |
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| Institution: | Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China |
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| Abstract: | Objective:To evaluate the effect and side-effect of combined chemotherapy with paclitaxel(PTX) plus cisplatin(DDP) in the treatment of advanced non-small cell lung cancer(NSCLC).Methods:Thirty-four patients with advanced NSCLC received PTX 135 mg/m2 by intravenous infusion on d1,and DDP 75 mg/m2 by intravenous infusion on d2-4.The treatment was repeated every 21 days,up to 2 cycles.Results:Thirty-four patients were evaluable for efficacy,with an overall rate of 41.2%.The response rate of squamous cell carci... |
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| Keywords: | lung neoplasms neoplasms/drug therapy carcinoma non-small cell lung paclitaxel cisplatin |
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