59例乳腺癌的临床与病理分析

目的研究59倒乳腺癌的临床特征、痛理与乳腺癌中ER、PR、p53、CerbB-2等的表达情况。方法时59例患者的临床资料、病理类型厦免疫组化结果进行回顾性分析。结果乳腺癌中ER、PR、p53、CerbB-2表达阳性率为27．1％、54．2％、47.5％、55.9％。p53表达阳性与乳腺癌组织学分级差异有统计学意义（P＜0．05）．与淋巴结转移差异有统计学意义（P＜0．01）。结论乳腺癌中，p53表达与CerbB-2表达相关，p53表达阳性不仅与细胞癌变有关，而且与癌细胞的浸润和转移有关。

Clinical and pathological analysis in 59 cases of breast cancer

Objective To research the clinical and pathological results in 59 cases of breast cancer,especially the expression of ER,PR,p53,CerbB2.Methods A retrospective analysis was made on 59 cases of breast cancer from Jan.2004 to Oct.2005.All of them were treated in our hospital.Results The positive rates of ER,PR,p53,CerbB-2 in breast cancer were 27.1%,54.2%,(47.5)%,55.9% respectively.A statistically significant relation was found between the presence of p53 and lymph node metastasis(P<0.01),the presence of p53 was also associated with the histological typing in breast cancer.(P<0.05).Conclusion There is a correlation between the expression of p53 and CerbB-2.p53 is assoicated with carcinogenesis development and local invasion in breast cancer.