|
|||||
|
|
| CYP4F2基因单核苷酸多态性与日本心肌梗死的相关性研究 | |
| 引用本文： | 付真彦,马依彤,杨毅宁,张建发,谢翔,王迎洪,中山智祥,佐藤直之,菅间薰. CYP4F2基因单核苷酸多态性与日本心肌梗死的相关性研究[J]. 新疆医科大学学报, 2008, 31(9) |
| 作者姓名： | 付真彦 马依彤 杨毅宁 张建发 谢翔 王迎洪 中山智祥 佐藤直之 菅间薰 |
| 作者单位： | 1. 新疆医科大学第一附属医院心脏中心,新疆,乌鲁木齐,830011;日本大学医学部先端医学讲座分子诊断学部门,东京1738610 2. 新疆医科大学第一附属医院心脏中心,新疆,乌鲁木齐,830011 3. 日本大学医学部先端医学讲座分子诊断学部门,东京,1738610 |
| 摘 要： | 目的:研究在日本不同性别中,CYP4F2基因单核苷酸多态性与心肌梗死的关系。方法:234例心肌梗死患者和248例年龄匹配的对照分别分为整体组,男性组,女性组。选择CYPF2基因的5个SNPs(rs3093105、rs3093135、rs1558139、rs2108622、rs3093200),应用TaqMan SNP基因分型的方法进行基因分型,并应用病例对照分析的方法进行相关性研究。结果:对于男性,心肌梗死患者rs2108622的G等位基因频率远远高于对照(P=0.001)。结论:CYP4F2基因rs2108622的G等位基因与日本男性心肌梗死相关,可做为日本男性心肌梗死的易感基因标记。 |
| 关 键 词： | CYP4F2 单核苷酸多态性 心肌梗死 |
Associated study between the polymorph ism of the CYP4 F2 gene and myocardial infarction in Japanese |
|
| FU Zhen-yan,MA Yi-tong,YANG Yi-ning,et al. Associated study between the polymorph ism of the CYP4 F2 gene and myocardial infarction in Japanese[J]. Journal of Xinjiang Medical University, 2008, 31(9) | |
| Authors: | FU Zhen-yan MA Yi-tong YANG Yi-ning et al |
| Abstract: | Obejective:The aim of the present study was to assess the association between the human CYP4F2 gene and myocardial infarction(MI)in Japanese,using a case-control study with a separate analysis of the gender groups.Methods:There were 234 MI patients and 248 control subjects genotyped for 5 SNPs of the human CYP4F2 gene(rs3093105,rs3093135,rs1558139,rs2108622,rs3093200).The data were assessed for 3 separate groups:thetotal subjects,men and women.Results:For men subjects,G allele of rs2108622 was significantly higher in the MI patients than the control subjects(P=0.001).Conclusions:The present results indicate that MI is associated with the G allele of rs2108622 in Japanese men and appears to be a useful genetic marker of EH in Japanese men. |
| Keywords: | CYP4F2 single-nucleotide polymorphism myocardial infarction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |