不同剂量左氧氟沙星治疗下呼吸道感染的成本-效果分析

目的:评价左氧氟沙星不同用药剂量治疗下呼吸道感染的成本-效果,为临床制订合理用药方案提供参考。方法:将315例下呼吸道感染患者随机分为3组,分别应用左氧氟沙星900mg(A组)、600mg(B组)、300mg(C组)进行治疗,观察临床疗效,并进行成本-效果分析。结果:3组总有效率分别为87·62%、84·76%、79·05%,细菌清除率分别为94·38%、90·80%、81·32%,不良反应发生率分别为6·67%、4·76%、3·81%;治疗成本分别为1116·75、997·82、826·46元;成本-效果比分别为12·74、11·77、10·45;AB组相对于C组的增量成本-效果比分别为33·87、30·01。结论:应用600mg左氧氟沙星进行治疗是比较合理的用药方案。

Cost-effectiveness Analysis of Levofloxacin at Different Dose for Lower Respiratory Tract Infections

OBJECTIVE:To evaluate the cost-effectiveness of levofloxacin at different dosage for lower respiratory tract infections so as to guide a rational drug use in the clinic.METHODS:315 patients with lower tract infections were randomly assigned to receive levofloxacin at different dosage:900mg (group A),600mg(group B)or 300mg(group C),clinical efficacies were observed and cost-effectiveness analysis was performed.RESULTS:The total effective rates of the 3 groups were 87.62%,84.76% and 79.05%,respectively,the germ-clearance rates were 94.38%,90.80% and 81.32%,respectively,the incidences of adverse effects were 6.67%,4.76% and 3.81%,respectively;The treatment costs of 3 groups were 1 116.75 yuan,997.82 yuan and 826.46 yuan,respectively;The cost-effectiveness ratios were 12.74,11.77 and 10.45,respectively;The incremental cost-effectiveness ratios of group A and B were 33.87 and 30.01 respectively as against group C.CONCLUSION: Levofloxacin at a dosage of 600mg is the optimal one for lower respiratory tract infections.