Neuroendocrine Tumor Imaging: Can 18F-Fluorodeoxyglucose Positron Emission Tomography Detect Tumors with Poor Prognosis and Aggressive Behavior? |
| |
Authors: | Claudio Pasquali Domenico Rubello Cosimo Sperti Piero Gasparoni Guido Liessi Franca Chierichetti Giorgio Ferlin Sergio Pedrazzoli |
| |
Affiliation: | (1) Department of Surgery, Institute of Semeiotica Chirurgica, University of Padua, F. Busonera Hospital, Via Gattamelata 64, 35128 Padua, Italy, IT;(2) Department of Nuclear Medicine, Castelfranco Veneto Hospital, Via Ospedale, 31033 Castelfranco Veneto, Italy, IT;(3) Department of Medicine, Castelfranco Veneto Hospital, Via Ospedale, 31033 Castelfranco Veneto, Italy, IT;(4) Department of Radiology, Castelfranco Veneto Hospital, Via Ospedale, 31033 Castelfranco Veneto, Italy, IT |
| |
Abstract: | n = 13). Tumor FDG uptake was increased in the primary lesion of all eight aggressive NETs; the tracer was shown also in lymph nodes, liver metastases, or both in five of six of them (83%). In four cases, additional unknown tumor sites undetected by CT scan were identified. A slight positivity was found in only one of eight cases with a slow-growing NET. The overall octreotide scintiscan sensitivity was 85%, but in the aggressive NETs it failed to detect the primary lesion in two of seven cases. Uptake of the tracer in some but not all tumor lesions in the same patient was seen by both FDG-PET and octreotide scintiscans. From our limited experience 18 F-FDG PET seems to be useful for identifying NETs characterized by rapid growth or aggressive behavior. Uptake of the FDG tracer by the tumor may be related to a worse prognosis. Despite the heterogeneity of tracer uptake in the various lesions of NETs with multiple tumor sites, FDG-PET was able to detect unsuspected distant metastases, contributing to better staging of advanced disease. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|