延胡索乙素对大鼠实验性心肌缺血的保护作用

目的 研究延胡乙素（dl-THP)对大鼠实验性心肌缺血的保护作用。方法 观察dl-THP对垂体后叶素（pit)所致大鼠心电图急性缺血性改变的预防作用以及对异丙肾上腺素（Iso)引起心肌损伤大鼠的保护作用。结果 dl-THP对垂体后叶素所致心电图改变有明显预防作用。能对抗Iso所致ECG的ST段升高。显著抑制心肌组织中磷酸肌激酶（CPK）、乳酸脱氢酶（LDH）的释放，降低血清CPK和LDH水平，保护心肌组织超氧化物歧化酶（SOD）活性，减少丙二醛（MDA）生成。结论 dl-THP对实验性心肌缺血有明显的保护作用。

Protective effects of dl-tetrahydropalmatine on experimental myocardial ischemia in rats

Objective To study the protective effect of dl tetrahydropalmatine(dl THP) on experimental myocardial ischemia in rats.Methods Acute myocardial ischemia ECG change was induced by pituitrin in rats and model of a myocardial ischemia by Isoprenaline(8 mg/kg),to observe the protective effect of dl THP.Results dl THP 20 mg/kg obviously antagonized ischemia ECG changes induced by ptuitrin in rats,in myocardial ischemia rats induced by Iso,dl THP 20 mg/kg ip significantly reduced ST and decreased CPK and LDH release and lowered the content of MDA,and increased SOD activity.Conclusion dl THP can protect ischemia myocardium and this action may be related to the prevention of myocardial lipid peroxicantion and improvement of myocardial metabolism.