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| D—天冬氨酸与帕金森模型鼠的相关性研究 | |
| 引用本文： | 刘承伟,卢洁,卢昕,马文领,蔡懿林. D—天冬氨酸与帕金森模型鼠的相关性研究[J]. 中国临床解剖学杂志, 2007, 25(2): 205-206 |
| 作者姓名： | 刘承伟 卢洁 卢昕 马文领 蔡懿林 |
| 作者单位： | 1. 桂林医学院解剖学教研室 2. 广西师范大学化学化工学院,桂林,541004 3. 第二军医大学海医系军队卫生学教研室,上海,200433 |
| 摘 要： | 目的:观察帕金森模型鼠中脑D-天冬氨酸的变化情况,探讨兴奋性神经递质右旋对映体与帕金森疾病的相关性。方法:成年C57-BL雄性小鼠随机分为对照组、模型组。应用柱前衍生高效液相色谱方法检测中脑D-天冬氨酸含量。结果:对照组与模型组中脑D-天冬氨酸含量无显著性差异。结论:中脑组织中内源性D-天冬氨酸的合成及转运不受神经毒素MPTP的影响,仍保持原有的动态平衡,可能没有参与帕金森病的发病机制。 |
| 关 键 词： | 帕金森病 小鼠 中脑 D-天冬氨酸 |
| 文章编号： | 1001-165X（2007）02-0205-02 |
| 收稿时间： | 2006-08-27 |
| 修稿时间： | 2006-08-27 |
The relationship between D-aspartic acid and Parkinson''''s disease mouse |
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| LIU Cheng-wei, LU Jie, LU Xin,et al.. The relationship between D-aspartic acid and Parkinson''''s disease mouse[J]. Chinese Journal of Clinical Anatomy, 2007, 25(2): 205-206 | |
| Authors: | LIU Cheng-wei LU Jie LU Xin et al. |
| Affiliation: | Department of Anatomy, Guilin Medical College, Guilin 541004 China |
| Abstract: | Objective:To explore the changes of the D-aspartic acid (Asp) in the midbrain of Parkinson's disease (PD) mice and study the relationship between D-type excitatory neurotransmitter Asp and PD. Methods:Adult C57-BL male mice were divided randomly into control group and PD model group. The concentration of D-Asp in midbrain was examined by high-performance liquid chromatography method. Result:The concentration of D-Asp was not different significantly between PD group and control group. Conclusions: The biosynthesis and the transportation of endogenous D-Asp in midbrain are not been affected by neurotoxicity MPTP and maintain its own dynamic balance. D-Asp may not participate in the PD pathogenesis. |
| Keywords: | Parkinson's disease mouse midbrain D-aspartic acid |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |