膀胱尿路上皮癌患者外周血T淋巴细胞凋亡蛋白Fas的表达 |
| |
引用本文: | 罗广承,刘莉莉,白培明,张楠根,颜志坚. 膀胱尿路上皮癌患者外周血T淋巴细胞凋亡蛋白Fas的表达[J]. 中华实验外科杂志, 2009, 26(7). DOI: 10.3760/cma.j.issn.1001-9030.2009.07.039 |
| |
作者姓名: | 罗广承 刘莉莉 白培明 张楠根 颜志坚 |
| |
作者单位: | 1. 厦门大学附属中山医院泌尿外科福建医科大学教学医院,361004 2. 厦门大学附属中山医院泌尿外科检验中心,361004 |
| |
摘 要: | 目的 探讨膀胱尿路上皮癌与Fas介导的血T淋巴细胞凋亡的关系.方法 应用流式细胞仪检测52例膀胱癌患者和37例健康对照者外周血CD4Fas、CD8Fas阳性T细胞.结果 膀胱癌患者外周血CIM、CD8Fas阳性T细胞分别为(20.74±9.02)%、(7.51±5.93)%,对照组分别为(15.68±5.58)%、(4.27±3.08)%,肿瘤组较对照组明显增加(P<0.01).浸润组CD8Fas阳性T细胞数为(5.83±3.95)%,表浅组为(5.83±3.95)%,浸润组较表浅组明显降低(P<0.05).复发组CD4、CD8Fas阳性T细胞与初发组比较筹异无统计学意义(P>0.05).结论 血T淋巴细胞Fas表达的异常可能在膀胱癌的发生发展中起重要的作用.
|
关 键 词: | 膀胱肿瘤 Fas蛋白 淋巴细胞 脱噬作用 |
Expression of Fas in peripheral blood T lymphocytes in patients with bladder urothelial carcinom |
| |
Abstract: | Objective To investigate the relationship between the Fas expression in peripheral blood T cells and bladder transitional cell carcinoma (TCC). Methods The Fas expression in peripheral blood T cells of 52 patients with TCC and 37 healthy people was detected by flowcytometry. The Fas-posi-tive rate was compared by t test between two designed groups. Results The Fas expression in CD4+ [(20.74±9.02)%] and CD8+[ (7.51±5.93 )% ] was increased in TCC patients as compared with controls ( P < 0. 01 ). Fas-positive CD8+ ceils were reduced in invasive TCC as compared with superficial TCC [ ( 5. 83±3.95 ) % vs ( 5. 83±3.95 ) %, P < 0.05 ], but there was no difference between primary and recurrent cases ( P > 0.05 ). Conclusion The abnormal Fas expression in peripheral blood T cells may play an important role in the development and progression of TCC. |
| |
Keywords: | Bladder neoplasm Fas protein Lymphocyte Apoptosis |
本文献已被 万方数据 等数据库收录! |
|